play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives. The Bacterial Vaccines group within Early Vaccines and Immune Therapies at Astra Zeneca is developing new and innovative vaccines against bacterial pathogens.
We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We're pioneering innovative research and exploring novel platforms to deliver vaccines against bacterial pathogens. We're industry-leading in bacteriology, immunology, protein engineering and translational science. We offer an outstanding and strong collaborative
network as part of the Astra Zeneca family. Astra Zeneca has a dynamic environment that champions collaboration and innovation. We attract top minds, and we nurture and build top talents.
The Senior Scientist is responsible for leading the efforts within a multidisciplinary research group to design and develop fermentation methods to optimize expression levels of recombinant vaccine antigens. This position will involve hands on fermentation work to develop, scale-up and characterize microbial culture processes for research and development of bacterial vaccine antigens. This position will support one or more projects and will be required to present, publish, and work with our intellectual
property team as a scientific leader. Experience: A successful candidate will be a well-grounded critical thinker with demonstrated ability to design and implement experiments to improve fermentation yields of engineered and wild-type bacteria to optimize expression of carbohydrate and recombinant vaccine antigens.
There is some flexibility in technical expertise for this position, but relevant experience is necessary in at least a few of the following areas: Special Skills/Abilities: Bacterial and eukaryotic culture and expression systems for carbohydrate and recombinant protein expression. Bacterial and eukaryotic culture in shake flask and scale-up into single use and re-useable bioreactors up to 10L.
Upstream process optimization to increase carbohydrate and recombinant protein expression in bacterial expression systems. Developing methods and SOPs for tech transfer from research to development Experience working on multidisciplinary project teams and supporting teams in a matrix management environment. Experience with bacterial bioconjugate vaccine expression is a plus. The candidate must be an effective oral and written communicator with a track record of quality publications. In addition, the individual must be dedicated to maintaining high laboratory standards, good record keeping, with high regard for quality and safety and must possess good organizational and interpersonal skills in a highly interactive multidisciplinary team-oriented environment.
Job Complexity: The candidate will work with minimal direction, is encouraged to be an independent problem solver, generate high quality and reproducible data and will be required report this data at departmental meeting and at project team meetings. Education: M. S. (5 -10 years post degree experience) or Ph D (3+ years post-degree experience) in microbiology, biochemistry, biochemical engineering, biotechnology or related scientific discipline.
M. S. (5 -10 years post degree experience) or Ph D (3+ years post-degree experience) in microbiology, biochemistry, biochemical engineering, biotechnology or related scientific discipline. Why Astra Zeneca? Make a significant impact to patients' lives around the globe. At Astra Zeneca, we 're dedicated to being a Great Place to Work, where you are empowered to push the boundaries of science and ignite your Entrepreneurial ambitious spirit. There's no better place to make a difference in medicine, patients, and society. An inclusive culture that champions diversity and teamwork.
Always committed to lifelong learning, growth, and development. Where can I find out more? Follow Astra Zeneca on Linked In/company/1603/Follow Astra Zeneca on Facebook/astrazenecacareers/Follow Astra Zeneca on Instagram/astrazeneca_careers/? hl=en Date Posted 01-Sep-2023 Closing Date Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be.
We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. All qualified applicants will receive consideration for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
MD, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives. The early Vaccines and Immune Therapies department at Astra Zeneca is developing new and innovative vaccines against bacterial pathogens.
We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We're pioneering innovative research and exploring novel platforms to deliver vaccines against viral and bacterial pathogens. We're industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part
of the Astra Zeneca family, as together we explore synergies between small and large molecules. Astra Zeneca has a dynamic environment that fosters collaboration and innovation.
We attract top minds and we nurture and build top talents. What You'll Do Design, develop, and implement in vitro and in vivo experiments to characterize and validate novel targets against bacterial pathogens. Essential For the Role: A Master's degree with 4-6 years of experience or Bachelor's degree with 6-10 years of equivalent experience in assay development, bacteriology, cell biology, and in-vivo work. A successful candidate will be a well-grounded critical thinker who can design and implement in vitro (bacterial
biofilm and cell attachment assays, bacteria functional activity assays such as serum bactericidal, opsonophagocytic killing and anti-cytotoxic assays) and in vivo studies (mouse lung infection, bacteremia) and correlate these activities to backss the potential efficacy of monoclonal antibodies against bacterial pathogens.
Broad and strong experience with relevant cellular and antibody-based immunological techniques to characterize and select anti-bacterial monoclonal antibodies (e. g. FACS, western blot, ELISA, bacterial culture, bacteria cell-based ELISA, surface and intra-cellular target staining for cytofluorimetry) is required. In vitro based assays to quantify pro-inflammatory mediators in animals (ELISA, Luminex and MSD platforms, cell-based assays) Experience in animal procedure (intraperitoneal, intranasal, intravenous injections), bacterial disease models (lung infection, bacteremia) The candidate must be an effective oral and written communicator with a demonstrable track record of quality publications.
In addition, the individual must be dedicated to maintaining high laboratory standards, good record keeping, with high regard to quality and safety and must possess good organizational and interpersonal skills in a highly interactive multidisciplinary team oriented environment.
Desireable for the role: Experience in molecular biology (e. g. bacteria mutagenesis, DNA manipulation and cloning, sequence analysis, plasmid vector design and construction) would be a plus. Why Astra Zeneca? At Astra Zeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being bold - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-medical company can be.
This means we're opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together. Interested? Come and join our journey. So, what's next! Apply today! Are you ready to bring new insights and fresh thinking to the table? Brilliant! We have one seat available, and we hope it's yours. To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel qualified for this opportunity.
If you know someone who would be a great fit, please share this posting with them. Where can I find out more? Check out our landing page for more information on our BPD group careers. /bpd Our Social Media, Follow Astra Zeneca on Linked In /company/1603/Follow Astra Zeneca on Facebook /astrazenecacareers/Follow Astra Zeneca on Instagram /astrazeneca_careers/? hl=en Date Posted 29-Sep-2023 Closing Date Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.
We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. All qualified applicants will receive consideration for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status.
Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
