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Here you can be part of a collaborative culture that will inspire you every day to be your best. Join us and you'll quickly learn why St. Jude is consistently ranked as one of The Commercial Appeal's Top Workplaces in the greater Memphis area. JOB SUMMARY : The Protein Technologies Center (PTC) in the Department of Structural Biology is seeking a highly motivated Scientist with experience in protein and membrane protein biochemistry to join a newly funded GPCR collaborative project to investigate the molecular determinants and fidelity of GPCR signaling in health and disease.

As part of the collaborative grant, the candidate will work closely with several partnering labs (Scott Blanchard,

Madan Babu, Robert Lefkowitz, Alice Ting, Jonathan Javitch, and Georgios Skiniotis). Successful candidates should have demonstrated competencies in the following areas: Cloning, expression, purification, and biochemically characterizing membrane proteins from mammalian and/or insect cell systems.

Prior experience with membrane protein or GPCR structural studies or functional assays. A significant contribution towards peer-reviewed research articles in the related scientific subject(s). Excellent record-keeping, communication, and presentation skills and ability to prepare high-quality manuscripts of findings for publication. Responsibilities: Design constructs, clone, express, and purify

GPCRs, G-proteins, arrestins, and other signaling proteins for structural, functional, and biophysical experiments to investigate structure-dynamics-function relationships.

Structure determination using either Cryo EM or x-ray methods. Work independently, leading a project from hypothesis to high-quality oral presentations and publications. Collaborate with an interdisciplinary group of researchers as part of a multi-institutional collaborative, including presentations to a broad audience. Train and mentor graduate students, post-docs, and visiting scientists. Instruct other staff in basic laboratory techniques and procedures. Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required.

Ph. D. in molecular biology, biochemistry, protein engineering, or any related discipline preferred. Minimum Experience: Seven (7) years of relevant post-degree work experience is required with a Bachelor's degree. Five (5) years of relevant post-degree work experience is required with a Master's degree. Three (3) years of relevant post-degree work experience is required with a Ph D. Benefits: Your health and well-being are important to us. That's why St. Jude Children's Research Hospital provides employees with high-quality benefits choices.

We are committed to ensuring our benefits are competitive and affordable. St. Jude continues to cover medical premiums for employees and offers low additional costs for dependents. View all the benefits offered including Medical & Prescription Drug Plans, Dental Plan, Vision Plan, Financial Security, Retirement Plan, Living Well - Employee Wellness Program, Time Off Programs, Educational Benefits, Family Friendly Benefits, and Benefits Unique to St. Jude. Diversity, Equity and Inclusion: St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion.

Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St.

Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. Have More in Memphis: Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis. From our world-renowned music scene to our eclectic mix of food and people. Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages.

Plus, Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can " Have More in Memphis. " Other Information St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St.

Jude.

creative, and fun group of scientists at St. Jude Children's Research Hospital. Our research program centers on: development of state-of-the-art genomic methods for understanding the global activities of genome editors, protein engineering to improve their capabilities for precise editing, and translation to autologous genome edited hematopoietic stem cell therapies.

About the job opportunity. We are seeking an outstanding and highly motivated Scientist or Lead Researcher to help lead efforts to develop personalized genome editing treatments for bone marrow failure disorders. We care deeply about the success of our scientists and this job is a unique opportunity to learn about genomics,

genome editing, and protein engineering while contributing to the development of future individualized genomic medicines at St. Jude, with room for career growth and advancement.

Dr. Tsai is co-leading a new Blue Sky Project called PARADIGM (Partnership to Advance Development of Individualized Genomic Medicines) with goal of developing personalized genome editing therapies for St. Jude patients. You would have opportunities to lead exciting projects that include: Protein engineering of improved novel CRISPR base and prime genome editors with human cell-based directed evolution. Understanding the structure-function relationship of mutations identified from high-throughput screens on the

activity of genome editors. Perform deep mutational scanning of CRISPR-Cas orthologues and effector domains important for precise genome editing such as deaminases and reverse transcriptases.

Define the outcome of engineered variants on genome editing repair outcomes using high-throughput genomic methods. Help develop laboratory automation workflows to perform scalable protein engineering. You would learn valuable laboratory skills that include: Genome engineering, high-throughput genomics, next-generation sequencing, protein engineering, structural biology, liquid handling automation, hematopoietic stem cell cell culture and transfection, and data science.

Project-dependent responsibilities could include: Engineer CRISPR base and prime editors with improved activity and specificities. Test new strategies to edit human hematopoietic stem cells for treatment of bone marrow failure disorders, focused on rapid development of editing strategies for rare patient-specific mutations. Optimize lead protein candidates by structure-guided design and high-throughput screening. Apply new machine learning techniques to guide protein engineering design. Analyze experimental outcomes and develop high-quality summaries towards manuscripts and grant applications.

Draft manuscripts and figures for publication in high-impact journals. Minimum Education and/or Training for the position include: A B. S. in a relevant field, such as genomics, molecular and cell biology, 1 year or more of hands-on, research laboratory experience. Excellent communication, organizational, and presentation skills. Scientist Minimum Experience: Seven (7) years of relevant post-degree work experience is required Five (5) years of relevant post-degree work experience is required with a Master's degree Three (3) years of relevant post-degree work experience is required with a Ph D Lead Researcher Minimum Experience: Five (5) years of relevant, post-degree work experience is required Two (2) years of relevant post-degree work experience is required with a Master's degree No experience is required with a PHD St.

Jude Benefits St. Jude Children's Research Hospital is one of the world's leading pediatric hospitals whose mission is to advances cures for catastrophic childhood diseases. Consistent with the vision of our founder, no child is denied treatment based on race, religion, or ability to pay. St. Jude has been consistently named one of the best companies to work for by Fortune, Glass Door, and others.

St. Jude offers excellent benefits, great salary, help with relocation, and actively fosters professional development. As part of your role, you will have opportunities to attend and present at national and internatl provides employees with high-quality benefits choices. We are committed to ensuring our benefits are competitive and affordable. St. Jude continues to cover medical premiums for employees and offers low additional costs for dependents. View all the benefits offered including Medical & Prescription Drug Plans, Dental Plan, Vision Plan, Financial Security, Retirement Plan, Living Well - Employee Wellness Program, Time Off Programs, Educational Benefits, Family Friendly Benefits, and Benefits Unique to St.

Jude. Diversity, Equity and Inclusion: St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment.

As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. Have More in Memphis: Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis.

From our world-renowned music scene to our eclectic mix of food and people. Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages. Plus, Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can " Have More in Memphis. " Other Information St. Jude is an Equal Opportunity Employer No Search Firms St.

Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.