facilities, state-of-the-art technologies, and extraordinary support for your research to ensure scientific progress is never halted from a lack of resources. At St. Jude, you will be part of a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve.
This is an exciting opportunity for a Scientist or Senior Scientist to join our Center for Advanced Genome Engineering (CAGE). The CAGE has three missions: 1) facilitate investigator-initiated genome editing projects using CRISPR-Cas9 2) perform independent R&D to evaluate and develop new genome editing techniques 3) to assist the gene and cell therapy programs
at St. Jude Children's Research Hospital. The Shondra Pruett-Miller laboratory offers a strong team-based environment where you will work collaboratively with other investigators across the institution to support their research needs and develop and improve genome engineering technologies.
In this position, you will lead the Custom CRISPR Library service. You will stay up to date on current CRISPR screening technologies and adapt and incorporate them into current workflows to aid St. Jude investigators with their research. Duties will also include designing, cloning, and analyzing CRISPR libraries designed for knockout, inhibition, and activation screens. You will help fellow team members
with their own designs and analyses. Your experience will also be used for developing and implementing bioinformatic workflows which aid CAGE lab members in CRISPR design and NGS analysis.
Successful candidates should display competencies in the following areas: Understanding of and experience with molecular biology techniques including DNA and RNA extractions, PCR, and plasmid cloning In depth knowledge and experience with CRISPR screens and analysis Excellent verbal and written communication skills Creative and self-motivated Experience with programming in python or other coding language is a plus Experience with liquid handling robots a plus Comfortable in a Linux environment and working on a cluster Comfortable working independently and as part of a team Ability to prioritize work based on need Ability to track and execute multiple projects at once Experience with Next-Generation Sequencing analysis is a plus Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required.
Minimum Experience: Scientist: Seven (7) years of relevant post-degree work experience is required with a Bachelor's degree. Five (5) years of relevant post-degree work experience is required with a Master's degree. Three (3) years of relevant post-degree work experience is required with a Ph D.
Senior Scientist: Five (10) years of relevant, post-degree work experience is required with a Bachelor's degree. Two (8) years of relevant post-degree work experience is required with a Master's degree. Three (6) years of relevant post-degree work experience is required with a Ph D. St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay.
Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.
Other Information St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
inter-disciplinary initiative at the Department of Structural Biology , St. Jude Children's Research Hospital. The Blue Sky Initiative " Seeing the Invisible in Protein Kinases " is supported by US $50 million in institutional funding (more information in the St.
Jude Strategic Plan 2022-2027 ). This large-scale project aims to leverage ultra-high field NMR, complemented with cryo EM, X-ray crystallography, data-science and computational approaches, to characterize the conformational landscape of the human kinome. We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases and creating new therapeutic opportunities. We
are looking for an accomplished and enthusiastic scientist to take a key leadership role in this project. This is a high-level staff position, and the Principal Scientist will: coordinate the activities of over 50 scientists across different teams who perform biochemistry, NMR, cryo EM, X-ray crystallography, and computational analyses of different kinases.
organize and integrate the data generated by those teams. participate in hiring additional staff scientists, as necessary. be the contact point for PIs and team leaders for information on all ongoing projects. identify kinases of biological and medical interest as targets. prepare materials for reports, presentations and publications.
take a lead on organizing internal scientific meetings. attend relevant international scientific meetings.
interact with other teams within St. Jude to identify scientific opportunities relevant for this project. Applicants should have a Ph. D. in a relevant subject; a background in structural biology or biophysics and a strong interest in molecular mechanisms are highly desirable. In addition, the ideal candidate should have a track record of exceptional organizational and problem-solving abilities; outstanding communication skills; be able to absorb, synthesize and integrate different types of information; work independently; and thrive on a highly collaborative and fast-moving environment.
St. Jude Children's Research Hospital offers a remarkable opportunity to perform cutting-edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement and training opportunities. St. Jude Children's Research Hospital consistently earns a Glassdoor Employee Choice Award and is named to its " Best Place to Work" list. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture.
Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive. Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required Minimum Experience: Fifteen (15) years of relevant post-degree work experience is required with a Bachelor's degree. Thirteen (13) years of relevant post-degree work experience is required with a Master's degree.
Eleven (11) years or relevant post-degree work experience is required with a Ph D. St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment.
As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. Other Information St. Jude is an Equal Opportunity Employer No Search Firms St.
Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
implement high throughput biochemical/biophysical assays and screens, including developing direct binding assays to quantify compound-protein interaction. The ideal candidate is familiar with high throughput screening and associated data analysis and quality control, and capable of developing/utilizing novel bioassays to solve challenging biology problems.
The Scientist reports to the Director of HTB Center and is expected to independently lead and implement collaborative projects; present or publish research results; and assist the Center Director in managing the daily operation of the Center. The HTB Center consists of those with advanced training in biology, chemistry, and engineering
who work together on target identification and validation, assay development, laboratory automation, high-throughput and high-content screening (up to 650K small molecules and genome-scale si RNAs), large-scale data processing, and management of scientific collaborations.
Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required. Minimum Experience: Seven (7) years of relevant post-degree work experience is required with a Bachelor's degree. Five (5) years of relevant post-degree work experience is required with a Master's degree. Three (3) years of relevant post-degree work experience is required with a Ph D. St. Jude Children's Research Hospital has
a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion.
Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive.
View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. Other Information St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St.
Jude.
of Structural Biology at St. Jude Children's Research Hospital seeks a Scientist to lead biochemical efforts related to the characterization and purification of novel nucleo-protein assemblies involved in genome integrity and organization. The scientist will work in collaboration with the cryo-EM center as well as closely with Kellogg lab members to pioneer new research directions.
This scientist will be given opportunities to travel in order to meet with collaborators and present at conferences. In addition, scientists will be given exploratory projects to establish new research directions in the areas of genome maintenance, DNA recombination, and DNA repair. The Kellogg lab uses cutting
edge Cryo-EM to investigate the molecular basis of genome modification and higher order genome structure. The Kellogg lab maintains a portfolio of ambitious projects ( Science, 2023 , Molecular Cell, 2023 , Science, 2023 , Nature, 2023 , PNAS, 2022 , Science, 2021 , and more ) which are supported by a generously funded and well-staffed research environment.
As one of the premier pediatric research institutions in the world, we know what can be achieved when the brightest scientific minds face the fewest barriers. That's why we provide world-class facilities , state-of-the-art technologies, and extraordinary support for your research to ensure that scientific progress is never halted from
a lack of resources. At St. Jude, you will be part of a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve.
Responsibilities: Collaborate with Dr. Kellogg to pioneer new research directions in Cryo-EM Mentor and train other lab members Maintain extensive knowledge of emerging technologies and develop novel applications. Employ and maintain effective communication with investigators, staff, and other personnel Advise and interact with faculty and other research staff on the management, design, and technical needs of research projects The ideal candidate will be solutions-oriented, and display rigorous thinking and strong intellectual honesty in all aspect of their work.
He/she will be team oriented and display a strong positive attitude even under time pressure, and will prioritize work that contribute to rapid scientific progress. St. Jude provides competitive compensation packages, including top-tier health benefits (including vision and dental), retirement account contributions, educational support (including college savings plans), and family care support. Click here for a comprehensive list of general employee benefits. This opportunity requires relocation to Memphis, TN.
Residents of Memphis enjoy a mild climate year-round, with a world class restaurant scene, vibrant cultural life, and affordable cost of living. To virtually meet Dr. Kellogg, check out The Plunge , a Cryo-EM Podcast she and two colleagues developed, co-wrote, and co-hosted. Dr. Kellogg was also recently featured on Cryo-Talk to talk about her life & work. Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required. Minimum Experience: Seven (7) years of relevant post-degree work experience is required with a Bachelor's degree. Five (5) years of relevant post-degree work experience is required with a Master's degree Three (3) years of relevant post-degree work experience is required with a Ph D St.
Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment.
As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. Other Information St. Jude is an Equal Opportunity Employer No Search Firms St.
Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
of Structural Biology at St. Jude Children's Research Hospital seeks a Senior Scientist to lead cryo-EM/cryo-ET focused projects focusing on understanding how naturally occurring and engineered macromolecular systems modify and organize the genome. The Senior Scientist will work in collaboration with the cryo-EM center and the volume EM center to correlate/integrate volumetric EM data with FIB-milling workflows.
The Kellogg lab uses cutting edge Cryo-EM to investigate the molecular basis of genome modification and higher order architecture. Maintaining a portfolio of ambitious projects aimed at furthering our fundamental understanding of the genome and how this is connected to biological
function ( Science, 2023 , Molecular Cell, 2023 , Science, 2023 , Nature, 2023 , PNAS, 2022 , Science, 2021 , and more ) These projects are supported by a generously funded and well staffed research environment.
As one of the premier pediatric research institutions in the world, we know what can be achieved when the brightest scientific minds face the fewest barriers. That's why we provide world-class facilities , state-of-the-art technologies, and extraordinary support for your research to ensure scientific progress is never halted from a lack of resources. At St. Jude, you will be part of a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates
into survival for the children we serve. Responsibilities: The primary day to day responsibilities will be focused on the design and execution of research aimed at understanding genome organization and higher order architecture, relying on single-particle cryo-EM and cryo-ET as his/her central research tool.
Contribute to the scientific training and professional development of postdocs, graduate students, and technicians in the Kellogg lab. Remain up to date with current technology and be constantly thinking about how to apply new innovations to achieve their research goals. Operate independently from planning experimentation to manuscript preparation.
Communicate project plans, progress, and issues in a timely manner to Dr. Kellogg and the team. Opportunities for career advancement, including attending and presenting at world-class conferences, will be provided. The ideal candidate will be solutions-oriented, and display rigorous thinking and strong intellectual honesty in all aspect of their work. He/she will be team oriented and display a strong positive attitude even under time pressure, and will prioritize work that contribute to rapid scientific progress. St. Jude provides competitive compensation packages, including top-tier health benefits (including vision and dental), retirement account contributions, educational support (including college savings plans), and family care support.
Click here for a comprehensive list of general employee benefits. This opportunity requires relocation to Memphis, TN. Residents of Memphis enjoy a mild climate year-round, with a world class restaurant scene, vibrant cultural life, and affordable cost of living. To virtually meet Dr. Kellogg, check out The Plunge , a Cryo-EM Podcast she and two colleagues hosted. Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required Minimum Experience: Ten (10) years relevant post-degree work experience is required Eight (8) years of relevant post-degree work experience is required with a Master's degree Six (6) years of relevant post-degree work experience is required with a Ph D St.
Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment.
Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.
Other Information St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
focused on epigenetic regulation of T cell functions, CD8 T cell exhaustion, and CD8 T cell memory differentiation. This knowledge of T cell biology uniquely positions our lab to analyze patient samples with the intent of developing strategies to optimize T-cell-based cancer therapies.
As a Scientist within the Youngblood lab, you will serve as an integral bridge between other scientists, clinicians, and bioinformatics research scientists within the Departments of Immunology and Bone Marrow Transplantation & Cellular Therapy to help coordinate our comprehensive effort to study the epigenetic regulation of the immune system in cancer patients. We are seeking a highly motivated and detail-oriented
individual with an interest in immunology and immunotherapy. Excellent communication and organization skills are required, as you will play a major role in coordinating research efforts among various labs within the institution.
In addition, the ability to work as a team player and collaborate effectively are essential for this position. The ideal applicant will conduct independent research and carry out diverse responsibilities, including: Applying research principles and relevant subject matter knowledge to help develop, design and conduct research projects. Ensuring project compliance with different policies, procedures, directives, and mandates. Supporting data collection and analytical
needs of research projects. Conducting literature reviews and write reports and manuscripts.
Salary is highly competitive (comparable to industry) and employee benefits are outstanding. Working at St. Jude provides the opportunity to make a tangible difference to pediatric cancer patient care and survival and St. Jude has been consistently ranked in Fortune magazine's " 100 Best Places to Work " list and is exceptionally positively reviewed on Glass Door. Minimum Education: Bachelor's degree in relevant scientific area is required. Minimum Experience: Seven (7) years of relevant post-degree work experience is required with a Bachelor's degree.
Five (5) years of relevant post-degree work experience is required with a Master's degree. Three (3) years of relevant post-degree work experience is required with a Ph D. Exposure to immunology or an appropriate scientific field is field. St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment.
As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.
Other Information St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
