Medical Laboratory Scientist : PCR Lab : Full Time Nights : Le Bonheur Childrens

why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St.

Jude, we encourage you to dream big and stop at nothing when it comes to finding cures and saving children. The laboratory of Dr. Christopher Tinkle within the Department of Radiation Oncology and Dr. Anang Shelat within the Department of Chemical Biol ogy and Therapeutics is seeking a highly motivated scientist interested in translating promising small molecule drug candidates into clinical trials for pediatric brain tumors.

The applicant will primarily conduct rigorous preclinical in vivo evaluation of drugs in clinical development for children with brain tumors using a unique collection of patient-derived orthotopic xenograft tumor models and genetically engineered models including such tumor types as medulloblastoma, ependymoma, and high-grade glioma.

The goal of such studies is to inform whether a clinical trial should or should not be pursued. The applicant is expected to work alongside domain experts in the biology of pediatric brain tumors, clinicians, and pharmacologists, as well as the various institutional shared resources devoted to translational science, in a collaborative project team environment.

In addition, the applicant will conduct focused in vitro studies to evaluate the pharmacokinetic and pharmacodynamics characteristics of lead compounds.

The applicant is expected to work closely with the institution's shared resources and laboratories within the Brain Tumor Program to conduct experiments. Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required. Minimum Experience: Seven (7) years of relevant post-degree work experience is required with a Bachelor's degree. Five (5) years of relevant post-degree work experience is required with a Master's degree. Three (3) years of relevant post-degree work experience is required with a Ph D.

Benefits Your health and well-being are important to us. That's why St. Jude Children's Research Hospital provides employees with high-quality benefits choices. We are committed to ensuring our benefits are competitive and affordable. St. Jude continues to cover medical premiums for employees and offers low additional costs for dependents. View all the benefits offered including Medical & Prescription Drug Plans, Dental Plan, Vision Plan, Financial Security, Retirement Plan, Living Well - Employee Wellness Program, Time Off Programs, Educational Benefits, Family Friendly Benefits, and Benefits Unique to St.

Jude. Diversity, Equity and Inclusion St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success.

With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. Have More in Memphis Get the best of big-city amenities mixed with all the charm of a small-town feel when you live in Memphis. From our world-renowned music scene to our eclectic mix of food and people.

Memphis is a place our employees are proud to call home. Our region enjoys a cost of living more than 20% lower than the national average and our state places no personal income tax on wages. Plus, Memphians spend five hours less per year in their daily commute compared to the national average. Learn how you can " Have More in Memphis. " Other Information St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities.

Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

and scale-up in one or more of the following areas: gene therapy vectors, Monoclonal Antibodies, small molecules (i. e. peptides, cytokines), recombinant proteins, or bacterial/viral/DNA vaccines. The position is responsible for the proper conduct of specific projects, collection and analysis of data.

The Therapeutics Production and Quality department within our Good Manufacturing Practices (GMP) facility is looking for a Scientist - Development to design and implement process development experiments with minimal supervision including both upstream and downstream unit operations. In this role you will perform small scale cell culture experiments, set up and run bioreactors for culture

of mammalian or bacterial cells, and optimize purification methods using various chromatography techniques. Experience in mammalian and bacterial cell culture, bioreactors, protein purification, plasmid DNA purification, tangential flow filtration and various other filtration techniques is preferred.

You will generate purified plasmid DNA and gene therapy vectors including Lentiviral. Job Responsibilities: Coordinate multiple aspects of projects/processes within area (GMP/ECTL) with guidance, and execute processes (e. g. tech transfer & scale-up runs, HPLC/biologic assays, manufacturing of cellular therapeutics) utilizing appropriate techniques, equipment, and methods. Provide inputs

regarding revisions to SOPs and/or process flows within area. Support development, documentation, and reporting of relevant experimental data (e.

g. production batch records, HPLC reports, summary reports for manufacturing campaigns). Monitor and document compliance with quality and regulatory requirements; and address deviations. Support monitoring and stocking of supplies, and calibration, maintenance, troubleshooting, and purchase of equipment within area. Instruct other staff in basic techniques, procedures, and systems within area (e. g. operations of c GMP equipment and control software). Perform other duties as assigned to meet the goals and objectives of the department and institution.

Maintains regular and predictable attendance. Minimum Education and/or Training: Bachelor's degree required. Master's OR Ph D preferred. Minimum Experience: Minimum Requirement: Bachelor's degree with 7+ years experience in relevant scientific area (e. g. GMP: chemistry, biology, chemical engineering, analytical chemistry, biotechnology; ECTL: cellular biology, molecular biology, immunology, biochemistry). Experience exception: 5+ years of experience in relevant area with Master's Experience exception: 3+ years of experience in relevant area with Ph D Prior experience in relevant area to own domain (e.

g. upstream/downstream c GMP experience, process development, HPLC/biological assays) strongly preferred. Experience in lab and scientific project coordination, maintenance, and other research support activities preferred. St Jude Employees receive: Excellent healthcare plans with zero to low health premium costs Onsite health clinic, shop, and exercise facilities Paid parental leave and adoption assistance Immigration Services Tuition Reimbursement St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion.

Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive.

View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. Other Information St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St.

Jude.

as exemplified in MLH Mission, Vision and Values. Education/Experience/Licensure Education/Formal Training Work Experience Credential/Licensure REQUIRED: Medical Laboratory Technology- Associates degree or Medical Laboratory Science or natural science Bachelor’s degree N/A Nationally Registered as a Medical Laboratory Scientist through ASCP, AMT or other approved agency.

PREFERRED: N/A N/A Medical Technologist TN Licensure (or Special Analyst) SUBSTITUTIONS ALLOWED: N/A N/A N/A Knowledge/Skills/Abilities Basic knowledge of laboratory procedures and instrumentation. Ability to effectively relate and communicate with internal and external customers. Basic knowledge of laboratory information

systems. Ability to organize tasks and projects work without close supervision to complete tasks. Key Job Responsibilities Performs accurate and appropriate testing of specimens received in the laboratory, according to established laboratory protocol and procedures.

Reports test results in a timely manner according to established laboratory protocols. Follows established procedures for laboratory quality control, ensures compliance with regulatory requirements, quality standards, compliance activities, and policies and procedures. Effectively manages resources such as productivity, supplies, instruments and equipment. Plans work and completes job responsibilities in an efficient and productive

manner. Physical Requirements The physical activities of this position may include climbing, pushing, standing, hearing, walking, reaching, grasping, kneeling, stooping, and repetitive motion.

Must have good balance and coordination. The physical requirements of this position are medium work - exerting up to 50 lbs. of force occasionally and/or up to 25 lbs. of force frequently. The Associate is required to have close visual acuity including color, depth perception, and field of vision to perform an activity, such as backssing patients, preparing and analyzing data and figures; transcribing; viewing a computer terminal; or extensive reading.

Frequent invasive and non-invasive patient contact. Exposure to patient body fluids as well as exposure to hazardous or poisonous materials. Ability to react quickly to emergency situations.

facilities, state-of-the-art technologies, and extraordinary support for your research to ensure scientific progress is never halted from a lack of resources. At St. Jude, you will be part of a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve.

This is an exciting opportunity for a Scientist or Senior Scientist to join our Center for Advanced Genome Engineering (CAGE). The CAGE has three missions: 1) facilitate investigator-initiated genome editing projects using CRISPR-Cas9 2) perform independent R&D to evaluate and develop new genome editing techniques 3) to assist the gene and cell therapy programs

at St. Jude Children's Research Hospital. The Shondra Pruett-Miller laboratory offers a strong team-based environment where you will work collaboratively with other investigators across the institution to support their research needs and develop and improve genome engineering technologies.

In this position, you will lead the Custom CRISPR Library service. You will stay up to date on current CRISPR screening technologies and adapt and incorporate them into current workflows to aid St. Jude investigators with their research. Duties will also include designing, cloning, and analyzing CRISPR libraries designed for knockout, inhibition, and activation screens. You will help fellow team members

with their own designs and analyses. Your experience will also be used for developing and implementing bioinformatic workflows which aid CAGE lab members in CRISPR design and NGS analysis.

Successful candidates should display competencies in the following areas: Understanding of and experience with molecular biology techniques including DNA and RNA extractions, PCR, and plasmid cloning In depth knowledge and experience with CRISPR screens and analysis Excellent verbal and written communication skills Creative and self-motivated Experience with programming in python or other coding language is a plus Experience with liquid handling robots a plus Comfortable in a Linux environment and working on a cluster Comfortable working independently and as part of a team Ability to prioritize work based on need Ability to track and execute multiple projects at once Experience with Next-Generation Sequencing analysis is a plus Minimum Education and/or Training: Bachelor's degree in relevant scientific area is required.

Minimum Experience: Scientist: Seven (7) years of relevant post-degree work experience is required with a Bachelor's degree. Five (5) years of relevant post-degree work experience is required with a Master's degree. Three (3) years of relevant post-degree work experience is required with a Ph D.

Senior Scientist: Five (10) years of relevant, post-degree work experience is required with a Bachelor's degree. Two (8) years of relevant post-degree work experience is required with a Master's degree. Three (6) years of relevant post-degree work experience is required with a Ph D. St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay.

Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.

Other Information St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.