areas where we believe we can really change the course of medicine and bring big new ideas to life. Astra Zeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death.
This Opportunity We are seeking a highly motivated and independent Senior Scientist with experience in radiomedical development to join our radioconjugate (RC) portfolio team within the Early Oncology Discovery group in Gaithersburg, MD USA. Requisites for this role include a proven track record of scientific excellence and several years of project leadership experience. As a
Senior Scientist in our group, you will be the tumor biology lead for emerging RC portfolio projects, working both with our internal project teams and with external partners to develop novel targeted alpha therapies.
As a core project lead, you will leverage your theoretical and practical expertise to deliver pre-clinical datasets, synthesize cross-functional learnings, establish program priorities, and advance the project through all stages of pre-clinical development. You will represent the project team in front of governance committees and will present program updates at other internal forums. In addition to your individual project leadership responsibilities, you will also provide
intellectual contributions and cross-functional support to RC teams across the portfolio.
Main Duties and Responsibilities You will be expected to serve as the tumor biology lead for one or more radioconjugate programs, working collaboratively with internal cross-functional teams and external partners to ensure the timely generation and dissemination of critical program data to enable project milestone decisions. As a highly organized, self-motivated individual with a strong background in cancer research and radiobiology, you will stay up to date with relevant technical, intellectual, and scientific expertise in tumor biology and cancer modelling, particularly as it relates to targeted radioconjugates, and have a genuine passion for this field of research.
Essential Requirements Ph D Degree with 0-3 years of experience, Master's Degree with 3+ years of experience, or a Bachelor's degree with 7+ years and project leadership experience in a relevant field related to tumor and radiation biology. Expertise in targeted radiomedical therapies, with broad knowledge of the field, is required for consideration of the candidate. Demonstrated ability to lead cross functional project teams. Solid understanding of radiation biology, cell biology, and/or biochemistry in the context of cancer, with a robust desire for continued learning.
Excellent communication, presentation, and interpersonal skills evidenced by a history of successful project delivery in team-oriented, collaborative environments. A consistent track record of productivity, as demonstrated by scientific publications in high quality peer-reviewed journals. Ensures own work, and work of peers, is compliant with Good Laboratory Practice, Safety, Health, and Environment standards and all other relevant internal Astra Zeneca standards and external regulations. Desirable Requirements Prior experience in the biomedical industry and familiarity handling data delivery through contract research organizations preferable but not required.
Direct, hands-on experience in residualization & saturation binding assays, PET-CT imaging, biodistribution studies, non-clinical dosimetry, and other pre-clinical radioimmunoconjugate methods is highly desirable. Experience with targeted alpha emitter therapeutics would be considered favorably. About Our Gaithersburg Oncology Hub Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC.
This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration. The Gaithersburg site offers a variety of amenities to help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center, game rooms, community garden and more.
This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. So, what's next- Are you already envisioning yourself joining our team? Good! We can't wait to hear from you! If you're curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner. Competitive remuneration and benefits apply We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.
Where can I find out more- Our Social Media, Follow Astra Zeneca on Linked In /company/1603/ Follow Astra Zeneca on Facebook /astrazenecacareers/ Follow Astra Zeneca on Instagram /astrazeneca_careers/? hl=en Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.
We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Date Posted 02-Nov-2023 Closing Date Astra Zeneca embraces diversity and equality of opportunity.
We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e. g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.
Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person. About Astra Zeneca in Gaithersburg, MD: Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world.
This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees
benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy.
This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. Summary of the group: The m RNA Drug Product Development Team is a part of the Dosage Form Design and Development group of Biomedical Development.
The team's purpose is to advance the development of m RNA products and processes, including manufacturing of lipid nanoparticles (LNPs) to deliver life-changing vaccines and medicines to our patients.
This purpose is realized through an application of a wide range of scientific disciplines converging to bridge between formulation and device capabilities and providing leadership from early research through CMC activities for m RNA delivery technologies. Areas of focus include: Strong collaboration with medical Sciences Advanced Drug Delivery team to enable identification and selection of appropriate lipids and LNP composition for downstream development activities Lead CMC activities across Dosage Form Design and Development to enable optimization of m RNA-LNPs towards an optimized platform state Advancement of formulation science as it pertains to stabilization of m RNA-LNPs Identification of new technologies to employ for product and process understanding Identification and initiation of key collaborations to advance m RNA-LNP platform development and product understanding both internally and externally Strategic insight for Technology Development in Dosage Form Design and Development Main Duties & Responsibilities: Serve as a key collaborator and partner for advancement of lipid selection and LNP composition with internal Advanced Drug Delivery team Serve as a leader in CMC Drug Product activities for Astra Zeneca m RNA programs providing oversight and execution of all elements of CMC delivery post Lead Optimization through clinical trials.
Lead the development of customized drug delivery formulations for non-viral delivery of various nucleic acids as needed to support therapeutic areas Provide technical expertise, design and execute experiments, analyze and present experimental data and sound recommendations Act as SME in project teams and across the organization Identification and evaluation of external technologies to support advancement of Astra Zeneca's internal m RNA-LNP manufacturing platform Education & Experience Requirements: Ph.
D. degree in a relevant discipline (such as Biopharmaceutics, Pharmaceutics, Chemical Engineering, or Drug Delivery) with 5+ years of relevant industry experience Required Skills: Good understanding/knowledge of the overall drug development process and knowledge of CMC attributes that define formulation robustness. Relevant industrial experience within drug delivery formulations for nucleic acid delivery (nanoparticle delivery technologies)Practical experience with nanoparticle formulation using various fabrication processes, analytical characterization and accurate data reporting Relevant experience with end-to-end nanoparticle and microparticle production processes for encapsulation of nucleic acids and biologics Flexibility and the ability to adjust to changing priorities and operate in a fast-paced industry environment.
Excellent oral and written communication skills; experience working in multidisciplinary teams Desired Skills: Leadership and stakeholder management skills Ability to navigate ambiguity and synthesize actionable next steps to move programs and strategies forward Track record of scientific competence in terms of publications, presentations and networking activities When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines.
In-person working gives us the platform to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility.
Join us in our unique and ambitious world. " Why Astra Zeneca? At Astra Zeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-medical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together.
Interested? Come and join our journey. So, what's next! Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours. Where can I find out more? Check out our landing page for more information on our BPD group careers. /bpd Our Social Media, Follow Astra Zeneca on Linked In /company/1603/ Follow Astra Zeneca on Facebook /astrazenecacareers/ Follow Astra Zeneca on Instagram /astrazeneca_careers/? hl=en Date Posted 07-Nov-2023 Closing Date Astra Zeneca embraces diversity and equality of opportunity.
We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e. g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.
Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
to the advancement of innovative Cell Therapy products by designing and conducting laboratory experiments, developing methodology, and generating and interpreting scientific data in a highly collaborative environment. Accountabilities: As a Scientist, Bioscience, you will conduct hands-on primary cell culturing, immune functional assays and phenotyping.
You will manipulate and characterize primary cells and cell lines, contribute to experimental plans and designs, backss and report data with high integrity, and communicate results to manager and team members. You will also support a team and work collaboratively with project managers to ensure the efficient relay of information and forward
translation of data. Essential Skills/Experience: BS/MS in a relevant scientific field and 3+ years of research experience in molecular and cellular biology of T and NK lymphocytes, cancer biology, tumor microenvironment, or related field Hands-on experience in the cell culture of established cell lines and/or primary human immune cells Basic expertise on flow cytometry acquisition and analysis In vivo experience with different mouse models Desirable Skills/Experience: Previous experience in the development of CAR-T cells, TCR-T cells, etc.
Familiarity with gene editing techniques (e. g. CRISPR/Cas, viral engineering, base editing, etc. ) Biotechnology or medical industry experience preferred.
Hands-on experience in in vitro NK/T-cell functional characterization including in vitro cytotoxicity assays, proliferation, cytokine measurement.
At Astra Zeneca, we are on a mission to eliminate cancer as a cause of death. As part of our Oncology R&D team, you will be at the forefront of applying science to studies and using innovative approaches to create new possibilities. We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. We lead through true collaboration, building collective wisdom by giving everyone a chance to input. Our commitment to patients and pioneering spirit are truly embedded and it's what makes our pipeline unique.
About Our Gaithersburg Oncology Hub Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration. The Gaithersburg site offers a variety of amenities to help keep our employees happy and healthy.
This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center, game rooms, community garden and more. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. Ready to make a difference? Apply now and join us in our mission to eliminate cancer as a cause of death. Please contact Bobbi Poole, our Talent Acquisition Partner. Closing Date: January 5, 2024 Competitive remuneration and benefits apply We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive.
We have a generous paid time off program and a comprehensive benefits package. Where can I find out more- Our Social Media, Follow Astra Zeneca on Linked In /company/1603/ Follow Astra Zeneca on Facebook /astrazenecacareers/ Follow Astra Zeneca on Instagram /astrazeneca_careers/? hl=en Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.
We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
Please contact us to request accommodation. Date Posted 07-Dec-2023 Closing Date 04-Jan-2024Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e.
g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
and Experimental Medicine (TSEM) department in the Respiratory and Immunology therapeutic area. As a department we promote an open and collaborative atmosphere, with a culture that is both science-based and patient-focused. Our mission is to understand disease mechanisms at the molecular level, identify the most effective targets and the right patient populations.
This role is located at one of our sites in either Gothenburg (Sweden) or Gaithersburg (US). Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions. We harness data science & AI to fast-forward our research. Making
sure work born in a lab can make a real difference, every day, impacting patients' lives across the world. What you will do In this role, you will work in a highly cross-functional and thriving environment together with specialists in sequencing, immunological and respiratory disease, as well as with other data science & bioinformatics experts.
For this role we are looking for an outstanding bioinformatician to enable translational science via integration of large-scale omics, clinical data, real world evidence and literature data to deliver precision medicine within our pipeline. Youll be identifying novel targets, biomarkers and patient sub-groups through innovative data analysis approaches
including utilization of clinical cohort omics data sets.
You will contribute to the identification of transformational precision medicine propositions to deliver life changing medicines to patients. You will be responsible for planning, performing and interpreting your analysis and communicate results. By applying state-of-the-art analytical methods, you will maximise the knowledge extrapolated from our growing omics data in complex diseases impacting the project progression and future treatment options for patients with unmet medical needs. Depending on your previous experience, your initial career level will be an Associate Principal Scientist or Senior Scientist.
Essential for the role MSc with extensive industry experience, or preferably, Ph D or equivalent in bioinformatics, data science, statistics, biostatistics, mathematics, or another similar subject area. Experience and proficiency in large-scale omics data analysis, integration and interpretation is a requirement. Omics include transcriptomics, single cell, proteomics (Olink, LC/MS), genomics, and other types of next generation sequencing (NGS) such as chromatin state approaches. Excellent coding skills in Python, R, or similar language appropriate for large scale omics analysis and experience with version control (Git/Bitbucket).
A good understanding of life sciences and how omics data can be utilised to derive biological insight will be a minimum requirement. Experience from applying this across different phases of medical discovery and development is a preference. Outstanding communication and collaboration skills, both with experts and non-experts, and with peers as well as stakeholders is expected. Our team is a collaborative group, so the ability to be comfortable working in a goal-oriented way, with a team focused approach is central to be successful in the role.
We believe you also have a high degree of independence and a proactive and delivery focused approach. Desirable for the role Experience in medical R&D and/or Post-doc experience. Molecular understanding of human diseases, patient stratification and biomarker-based endpoint generation, preferentially in respiratory and immunological disorders. Track record of applying bioinformatic analysis to drive projects in drug discovery or development in an industrial or academic setting. Broad experience applying machine learning methods such as random forests, clustering, dimensionality reduction in a systems biology or systems medicine context.
Working in a Linux environment, ideally with experience of cluster or cloud computing (e. g. AWS or Azure). Experience from leading projects with internal groups/external collaborators. Experience working within cross-functional teams. Why Astra Zeneca? At Astra Zeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.
Work policy When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. What's next?
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application (including CV and cover letter), no later than January 12, 2024. If you're curious to know more about the position, please get in touch with hiring manager Greet De Baets at xyz X@. Where can I find out more? Follow Astra Zeneca on Linked In: /company/1603/Follow Astra Zeneca on Instagram: /astrazeneca_careers/? hl=en Read more about Biomedicals R&D: /r-d. html Date Posted 20-dec. -2023 Closing Date 19-dec. -2023Our mission is to build an inclusive and equitable environment.
We want people to feel they belong at Astra Zeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
