provider solution, which is a unique partnership that allows our customers to leverage the experience of our staff, while allowing you, the employee, to gain direct experience working onsite at a medical/ biomedical company, all while maintaining full-time benefits.
Essential Functions: The target client is a leading medical group responsible for the development of CHO based production cell lines, next-gen cell line engineering efforts and baseline upstream process development for innovative recombinant protein/adjuvanted vaccine projects and platforms. The target client is looking for a motivated professional, specialized in mammalian cell culture science (primary CHO). This role will
play a significant role in shaping current and next generation leading vaccine platforms to accelerate addressing unmet medical needs, an exciting field having a direct impact into patients and global health.
This role provides the opportunity to integrate a diverse group of top talented experts in vaccines' industry, lead key activities and further grow and progress in your career. Main core responsibilities: Implementation of state-of-art high throughput upstream process tools (AMBRs) to evaluate the process suitability of CHO cell lines for commercial manufacture of recombinant protein vaccine products. Serve as a key team player to support project documentation and CMC regulatory
submissions (including raw material control section and cell line derivation report) Education and Experience: Bachelor's degree in a degree related in Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology, Bioengineering, or a related scientific field.
Previous industry experience that provides the knowledge, skills, and abilities to perform the job: Bachelor's degree 4+ years of experience Qualifications: Hands-on experience with aseptic mammalian (CHO cell preferred) cell line development. Hands-on experience with benchtop bioreactor operation Good understanding with mammalian fed batch process. Experience with good documentation practices and reports as evidenced by successful execution of pipeline projects, conference proceeding and peer-review publication.
In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role. Preferred Qualifications: Prior experience in the cell culture for commercial vaccines and biologicals production with a strong CMC understanding. Prior experience in the high-throughput robotic cell culture tools (AMBR15, AMBR250, Cedex and Novaflex), or other high-throughput robotic system.
Experience with common protein-based analytic assays (including western-blot and ELISA ) for early product quantity and quality backssment to support cell line selection. Working Environment: PPD values the health and well being of our employees. We support and encourage individuals to create a healthy and balanced environment where they can thrive. Below is listed the working environment/requirements for this role: Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner. Able to work upright and stationary and/or standing for typical working hours.
Able to lift and move objects up to 25 pounds Able to work in non-traditional work environments. Able to use and learn standard office equipment and technology with proficiency. May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments. Able to perform successfully under pressure while prioritizing and handling multiple projects or activities. As a condition of employment with Thermo-Fisher, in this role, you must have received your Covid-19 vaccine and you must disclose proof of your vaccination status upon employment.
play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives. The Bacterial Vaccines group within Early Vaccines and Immune Therapies at Astra Zeneca is developing new and innovative vaccines against bacterial pathogens.
We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We're pioneering innovative research and exploring novel platforms to deliver vaccines against bacterial pathogens. We're industry-leading in bacteriology, immunology, protein engineering and translational science. We offer an outstanding and strong collaborative
network as part of the Astra Zeneca family. Astra Zeneca has a dynamic environment that champions collaboration and innovation. We attract top minds, and we nurture and build top talents.
The Senior Scientist is responsible for leading the efforts within a multidisciplinary research group to design and develop fermentation methods to optimize expression levels of recombinant vaccine antigens. This position will involve hands on fermentation work to develop, scale-up and characterize microbial culture processes for research and development of bacterial vaccine antigens. This position will support one or more projects and will be required to present, publish, and work with our intellectual
property team as a scientific leader. Experience: A successful candidate will be a well-grounded critical thinker with demonstrated ability to design and implement experiments to improve fermentation yields of engineered and wild-type bacteria to optimize expression of carbohydrate and recombinant vaccine antigens.
There is some flexibility in technical expertise for this position, but relevant experience is necessary in at least a few of the following areas: Special Skills/Abilities: Bacterial and eukaryotic culture and expression systems for carbohydrate and recombinant protein expression. Bacterial and eukaryotic culture in shake flask and scale-up into single use and re-useable bioreactors up to 10L.
Upstream process optimization to increase carbohydrate and recombinant protein expression in bacterial expression systems. Developing methods and SOPs for tech transfer from research to development Experience working on multidisciplinary project teams and supporting teams in a matrix management environment. Experience with bacterial bioconjugate vaccine expression is a plus. The candidate must be an effective oral and written communicator with a track record of quality publications. In addition, the individual must be dedicated to maintaining high laboratory standards, good record keeping, with high regard for quality and safety and must possess good organizational and interpersonal skills in a highly interactive multidisciplinary team-oriented environment.
Job Complexity: The candidate will work with minimal direction, is encouraged to be an independent problem solver, generate high quality and reproducible data and will be required report this data at departmental meeting and at project team meetings. Education: M. S. (5 -10 years post degree experience) or Ph D (3+ years post-degree experience) in microbiology, biochemistry, biochemical engineering, biotechnology or related scientific discipline.
M. S. (5 -10 years post degree experience) or Ph D (3+ years post-degree experience) in microbiology, biochemistry, biochemical engineering, biotechnology or related scientific discipline. Why Astra Zeneca? Make a significant impact to patients' lives around the globe. At Astra Zeneca, we 're dedicated to being a Great Place to Work, where you are empowered to push the boundaries of science and ignite your Entrepreneurial ambitious spirit. There's no better place to make a difference in medicine, patients, and society. An inclusive culture that champions diversity and teamwork.
Always committed to lifelong learning, growth, and development. Where can I find out more? Follow Astra Zeneca on Linked In/company/1603/Follow Astra Zeneca on Facebook/astrazenecacareers/Follow Astra Zeneca on Instagram/astrazeneca_careers/? hl=en Date Posted 01-Sep-2023 Closing Date Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be.
We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. All qualified applicants will receive consideration for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
provider solution, which is a unique partnership that allows our customers to leverage the experience of our staff, while allowing you, the employee, to gain direct experience working onsite at a medical/ biomedical company, all while maintaining full-time benefits.
Essential Functions: The target client is a leading group responsible for the development of CHO based production cell lines, next-gen cell line engineering efforts and baseline upstream process development for innovative recombinant protein/adjuvanted vaccine projects and platforms. The target client is looking for a motivated professional, specialized in early in-process analytics, protein vaccines. This role will play a
significant role in shaping current and next generation leading vaccine platforms to accelerate addressing unmet medical needs, an exciting field having a direct impact into patients and global health.
This role provides the opportunity to integrate a diverse group of top talented experts in vaccines' industry, lead key activities and further grow and progress in your career. Main core responsibilities : 1. Development and implementation of in-process analytical methods (content, potency and process- and product-related impurities) to support cell line and early process development projects as well as next-gen cell line engineering. 2. Key team players to interact with the discovery and
preclinical teams and collaborate proactively to support antigen selection and early product understanding workflows to enable swift CMC onboarding.3.
Implement platform dd PCR and NGS based methods for testing cell line genetic stability and support next-gen cell line engineering effort. At PPD, part of Thermo Fisher Scientific we hire the best, develop ourselves and each other, and recognize the power of being one team. We offer continued career advancement opportunities, award winning training and benefits focused on the health and wellbeing of our employees. To learn how PPD, part of Thermo Fisher Scientific can advance your career, apply now! Education and Experience: Bachelor's degree or equivalent and relevant formal academic / vocational qualification Previous industry experience that provides the knowledge, skills, and abilities to perform the job: Scientist: With a bachelor's degree comparable to 2+ years of experience In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.
Knowledge, Skills and Abilities: Basic Qualifications: 1+ year hands-on solid experience with implementation of state-of-art multiplex immuno analytics, e.
g. ELISA, Octet, Biacore, Luminex and MSD for complex protein or biologics characterization. Hands-on experience with molecular analytics, e. g. real-time PCR or digital droplet PCR Preferred Qualifications: Experience with designing and implementing in-process analytics for content, potency and impurity. Experience with Quality by Design with demonstrated capability to develop fit-for-purpose high throughput in process analytics to support cell line development and cell line engineering. Experience with advanced NGS and Omics-techniques for transgene copy number/integrity/structure variant characterization.
Advanced knowledge of structure biology and protein engineering. Working Environment: PPD, part of Thermo Fisher Scientific values the health and well being of our employees. We support and encourage individuals to create a healthy and balanced environment where they can thrive. Below is listed the working environment/requirements for this role: Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner. Able to work upright and stationary and/or standing for typical working hours.
Able to lift and move objects up to 25 pounds. Able to work in non-traditional work environments. Able to use and learn standard office equipment and technology with proficiency. May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments. Able to perform successfully under pressure while prioritizing and handling multiple projects or activities. As a condition of employment with PPD, in this role, you must have received your Covid-19 vaccine and you must disclose proof of your vaccination status upon employment.
