Biosciences is a neuroscience-focused, biomedical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders.
The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson's disease, endometriosis and uterine fibroids, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines
to ease the burden of debilitating diseases and disorders, because you deserve brave science. in collaboration with Abb Vie About the Role: Neurocrine is expanding our R&D chemistry capabilities.
In this exciting new role, you will be instrumental in the success of our growing computational chemistry team. The successful candidate will be responsible for the execution of computational-driven methodologies to help design optimized compounds with balanced properties (targets, DMPK, in-vivo). Your industry knowledge will include expertise in machine learning tools, and analytics, along with expertise with structure-based design methods to support drug discovery projects in the industry,
for our growing pipeline. Your Contributions (include, but are not limited to): Projects could range from early lead identification to the late-stage optimization of advanced projects.
In particular, you will be able to join and potentially lead the development of an in-silico modeling platform within the Chemistry Department. As an active contributing member of multi-disciplinary drug discovery projects comprised of Medicinal Chemists, Biologists, DMPK & toxicologists there will be enormous opportunities to impact projects, as well as ample collaboration opportunities to share and learn from similar ML-derived predictive modeling efforts in other Neurocrine's R&D functions.
Expertise with structure-based design methods to support drug discovery projects in the industry. Experience in machine learning approaches in their application to compound design and drug discovery is essential, which would include modern AI such as Deep Learning, Generative Modeling and Knowledge Graphs, and/or classical methods of Random Forest, KPLS, SVM, etc. Knowledge about ML environments and libraries such as Tensor Flow, Py Torch, RDKit, Scikit-learn, etc. is highly desirable as well as a deep understanding of validation metrics behind ML models. Additional suggested modern contextual topics may include meaningful connection of model predictions back to chemical structures, Polypharmacology (multiple targets with similar compounds), Protein Dynamics/ Ligand Binding, Data visualization metrics, and more.
Requirements and essential functions A collaborative & team-oriented mindset is essential Responsible for the communication and presentation of computationally derived results to the discovery project teams to facilitate effective decision-making. Familiarity with well-known commercial molecular modeling software suites is also desirable such as Schrodinger, CCG, or Open Eye.
Experience with Molecular Modeling domains is required, as applied to compound design and optimization such as Pharmacophore Analyses, Library Design, virtual HTS, Diversity/Similarity Analyses, Scaffold Hopping. A demonstrated success with an overall application of several integrated approaches (ML-derived predictions, Modeling SBD/ LBD) to progressing compound design contextual in drug discovery, is highly desirable and will serve as a strong bonus to consideration. Publications, posters, or documented examples would be helpful. Comfortable with routine programming & scripting including Python, C++, and/or R.
Experience with Pipeline Pilot or Knime would be an asset. Linux administration is desirable but not essential. Exposure to harnessing large datasets including public domain datasets of chemistry related to various targets and/or chemogenomic nature would be an asset. Other duties as assigned BS degree in chemistry or related area with 4 years + relevant experience including utilizing any or all of the following Protein-ligand, modeling, Molecular Dynamics, and Homology Modeling MS degree in chemistry and 4 years of similar experience noted above OR Ph.
D. in computational chemistry or related field with 2+ years of related industry experience. #AD1Neurocrine Biosciences is an EEO/AA/Disability/Vets employer. We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description. The annual base salary we reasonably expect to pay is $103,200.00-$149,700.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills.
In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.
Biosciences is a neuroscience-focused, biomedical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders.
The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson's disease, endometriosis and uterine fibroids, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines
to ease the burden of debilitating diseases and disorders, because you deserve brave science. in collaboration with Abb Vie About the Role: We are looking for a collaborative and highly motivated scientist to join our Research team.
The primary role will be to use cell engineering techniques to generate novel, physiologically relevant cell line/disease models, perform characterization as well as develop cell-based/potency assays to support gene therapy projects. He/she will also be involved in the production and support of more complex, disease relevant primary/i PSC derived cellular models when needed. The ideal candidate must have outstanding written and verbal communication skills,
a strong work ethic, and be able to multitask and prioritize responsibilities.
This candidate will be able to work together with his or her supervisor and the team to seamlessly provide consistent support for drug discovery and development. Your Contributions (include, but are not limited to): This scientist will be an innovative thinker with the ability to work independently, design and carry out experiments and propose creative solutions to challenging problems Provide expertise for cell model development using cell engineering/transfection techniques (Crispr/Cas9), cell culture expansion and differentiation, scale up/down and cell biology/function Provide molecular and cell biology support to execute standard cell culture processes including transfection, selection, sub-cloning, clonal expansion, and banking as well as cell model characterization Design and perform in vitro cell based and potency assays to support Gene Therapy research projects Work in the lab independently and in a collaborative environment with minimal guidance to explore, develop and validate novel models for neurological disorders Help to identify, evaluate, and, where applicable, implement novel methods or technologies that would enhance workflow efficiencies and/or improve the quality of cell model deliverables Requirements: BA/BS in Biochemistry, Biology, bioengineering or a related fields and 7+ years of Biotechnology industry experience including gene therapy-specific techniques and cell model development with emphasis in Neuroscience Ph D degree in relevant discipline and 3+ years as noted above.
Biotech/medical industry experienced preferred Strong experience in developing cell models for neurological diseases, using different immortalized cell lines, neuroblastoma and/or i PSC culture/differentiation into neuronal types and cell clone characterization methods to support gene therapy projects Prior hands-on experience in biochemistry techniques including (but not limited to) q PCR, d PCR, western blot, immunoassays, FACs analysis, protein assay development and data analysis Demonstrated hands on experience with viral (preferably AAV) and/or non-viral gene delivery for gene expression upregulation/downregulation as well as in vitro genome editing Required experience developing new biochemical and cell-based/potency assays Experience using modern automation, LIMS, data analysis and informatics systems is a plus Demonstrated ability to multi-task and be highly productive in a multidisciplinary, fast-paced and diverse environment Ability to work as part of a team; may train other team colleagues Strong communications, problem-solving, analytical thinking skills #LI-AD1Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.
We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.
The annual base salary we reasonably expect to pay is $103,200.00-$149,700.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills. In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.
Biosciences is a neuroscience-focused, biomedical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders.
The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson's disease, endometriosis and uterine fibroids, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines
to ease the burden of debilitating diseases and disorders, because you deserve brave science. in collaboration with Abb Vie About the Role: This Scientist will guide the design, development, and execution of methods for the characterization and analysis of gene therapy and other biologic-based development candidates for research, pre-clinical, and clinical use.
They will collaborate with Analytical Development leads in the lab-based analysis to determine the content and potency properties of proteins and gene therapy vectors, working cross-functionally to establish the laboratory standards for determining strength, potency and quality attributes for these late discovery and early development
candidates. Your Contributions (include, but are not limited to): Supports activities associated with the development and execution of biologically based methods relevant to protein and gene therapy products for analytical development in a Research and Development environment Performs the activities needed for in vitro analytical testing to screen engineered vector constructs including transfection and transduction read-outs Establishes assay development parameters such as specificity, linearity, precision, and repeatability of biological assays through optimization of experimental methods is preferred Demonstrates expertise in multi-well plate bioassay optimization, including ELISA-based and protein characterization methods is preferred Understands release testing methods used for viral Gene Therapy products; AAV preferred Works with a cross-function team to maintain cell lines for biologically based potency assays for Gene Therapy products, specifically AAV Contributes through authorship and review of documents for the development and establishment of analytical methods for product characterization to support research and development activities including the in-process and release testing for material manufactured for research and IND-enabling studies Represents the group during discussions with Research, Development, and collaborative stakeholders to build scientific knowledge, capabilities, and strategies by providing protein and gene therapy product characterization data to support research and product development decisions Contributes to the development of, and effective execution of, science-driven, phase appropriate, and risk-based process development strategies to support development projects in discovery and development phase programs to lead candidate nomination with responsibility to help tech transfer activities for further GMP assay development, testing Identifies and resolves technical problems through scientific understanding, options backssment, and application of innovative solutions Prepares clear and concise technical reports and participates in project team discussions Carries an internal sense of urgency to execute on strategy, vision, and direction set by line management Contributes to the decision-making processes within each project team by actively engaging in scientific and technical discussions Performs other duties as assigned Requirements: BA/BS in Biochemistry, Biology, or other relevant discipline and 5+ years of Biotechnology industry experience in biologics including gene therapy-specific techniques OR Master's/Ph D in relevant discipline and 1+ years as noted above Familiarity with product and analytical processes such as Quality by Design (Qb D) and Quality Risk Management (QRM) tools to support Clinical Manufacturing at the Dev Candidate stage in a phase-appropriate fashion, to support later phase CMC activities is a plus.
Knowledge of protein and gene therapy biology with a good understanding of testing/characterization methods required Good knowledge of cell-based methods associated with bioanalytical analytical method development (e.
g. TCID50, Potency assay, viral transduction, and ELISA methods) preferred Some experience with methods in AAV characterization (e. g. Mesoscale Diagnostics, Alpha Lisa, TCID50, Wes/JESS protein expression, Full versus Empty Characterization assays, DLS) preferred Familiar with laboratory operations, including instrument set up, maintenance, and safety Familiar level knowledge of the biologics drug development process is recommended Familiar knowledge of GLP and GMP requirements as they pertain to protein and gene therapy process development and Quality Control (QC) testing is a plus Recognizes fundamental anomalies in data points and identifies issues in experiments / processes Understands how to think outside of the technical process and consider the impact decisions will have on the broader scientific goals Strong knowledge of one scientific discipline Good knowledge of scientific principles, methods, and techniques Good knowledge and demonstrated ability working with a variety of laboratory equipment/tools Ability to work as part of a team Strong computer skills Good communications, problem-solving, analytical thinking skills Detail oriented Ability to meet deadlines Good project management skills #LI-AD1Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.
We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description. The annual base salary we reasonably expect to pay is $84,100.00-$122,050.00. Individual pay decisions depend on various factors, such as primary work location, complexity and responsibility of role, job duties/requirements, and relevant experience and skills.
In addition, this position offers an annual bonus with a target of 20% of the earned base salary and eligibility to participate in our equity based long term incentive program. Benefits offered include a retirement savings plan (with company match), paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans.
