areas where we believe we can really change the course of medicine and bring big new ideas to life. Astra Zeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death.
This Opportunity We are seeking a highly motivated and independent Senior Scientist with experience in radiomedical development to join our radioconjugate (RC) portfolio team within the Early Oncology Discovery group in Gaithersburg, MD USA. Requisites for this role include a proven track record of scientific excellence and several years of project leadership experience. As a
Senior Scientist in our group, you will be the tumor biology lead for emerging RC portfolio projects, working both with our internal project teams and with external partners to develop novel targeted alpha therapies.
As a core project lead, you will leverage your theoretical and practical expertise to deliver pre-clinical datasets, synthesize cross-functional learnings, establish program priorities, and advance the project through all stages of pre-clinical development. You will represent the project team in front of governance committees and will present program updates at other internal forums. In addition to your individual project leadership responsibilities, you will also provide
intellectual contributions and cross-functional support to RC teams across the portfolio.
Main Duties and Responsibilities You will be expected to serve as the tumor biology lead for one or more radioconjugate programs, working collaboratively with internal cross-functional teams and external partners to ensure the timely generation and dissemination of critical program data to enable project milestone decisions. As a highly organized, self-motivated individual with a strong background in cancer research and radiobiology, you will stay up to date with relevant technical, intellectual, and scientific expertise in tumor biology and cancer modelling, particularly as it relates to targeted radioconjugates, and have a genuine passion for this field of research.
Essential Requirements Ph D Degree with 0-3 years of experience, Master's Degree with 3+ years of experience, or a Bachelor's degree with 7+ years and project leadership experience in a relevant field related to tumor and radiation biology. Expertise in targeted radiomedical therapies, with broad knowledge of the field, is required for consideration of the candidate. Demonstrated ability to lead cross functional project teams. Solid understanding of radiation biology, cell biology, and/or biochemistry in the context of cancer, with a robust desire for continued learning.
Excellent communication, presentation, and interpersonal skills evidenced by a history of successful project delivery in team-oriented, collaborative environments. A consistent track record of productivity, as demonstrated by scientific publications in high quality peer-reviewed journals. Ensures own work, and work of peers, is compliant with Good Laboratory Practice, Safety, Health, and Environment standards and all other relevant internal Astra Zeneca standards and external regulations. Desirable Requirements Prior experience in the biomedical industry and familiarity handling data delivery through contract research organizations preferable but not required.
Direct, hands-on experience in residualization & saturation binding assays, PET-CT imaging, biodistribution studies, non-clinical dosimetry, and other pre-clinical radioimmunoconjugate methods is highly desirable. Experience with targeted alpha emitter therapeutics would be considered favorably. About Our Gaithersburg Oncology Hub Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC.
This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration. The Gaithersburg site offers a variety of amenities to help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center, game rooms, community garden and more.
This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. So, what's next- Are you already envisioning yourself joining our team? Good! We can't wait to hear from you! If you're curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner. Competitive remuneration and benefits apply We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.
Where can I find out more- Our Social Media, Follow Astra Zeneca on Linked In /company/1603/ Follow Astra Zeneca on Facebook /astrazenecacareers/ Follow Astra Zeneca on Instagram /astrazeneca_careers/? hl=en Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.
We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Date Posted 02-Nov-2023 Closing Date Astra Zeneca embraces diversity and equality of opportunity.
We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e. g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.
Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person. About Astra Zeneca in Gaithersburg, MD: Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world.
This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees
benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy.
This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. Summary of the group: The m RNA Drug Product Development Team is a part of the Dosage Form Design and Development group of Biomedical Development.
The team's purpose is to advance the development of m RNA products and processes, including manufacturing of lipid nanoparticles (LNPs) to deliver life-changing vaccines and medicines to our patients.
This purpose is realized through an application of a wide range of scientific disciplines converging to bridge between formulation and device capabilities and providing leadership from early research through CMC activities for m RNA delivery technologies. Areas of focus include: Strong collaboration with medical Sciences Advanced Drug Delivery team to enable identification and selection of appropriate lipids and LNP composition for downstream development activities Lead CMC activities across Dosage Form Design and Development to enable optimization of m RNA-LNPs towards an optimized platform state Advancement of formulation science as it pertains to stabilization of m RNA-LNPs Identification of new technologies to employ for product and process understanding Identification and initiation of key collaborations to advance m RNA-LNP platform development and product understanding both internally and externally Strategic insight for Technology Development in Dosage Form Design and Development Main Duties & Responsibilities: Serve as a key collaborator and partner for advancement of lipid selection and LNP composition with internal Advanced Drug Delivery team Serve as a leader in CMC Drug Product activities for Astra Zeneca m RNA programs providing oversight and execution of all elements of CMC delivery post Lead Optimization through clinical trials.
Lead the development of customized drug delivery formulations for non-viral delivery of various nucleic acids as needed to support therapeutic areas Provide technical expertise, design and execute experiments, analyze and present experimental data and sound recommendations Act as SME in project teams and across the organization Identification and evaluation of external technologies to support advancement of Astra Zeneca's internal m RNA-LNP manufacturing platform Education & Experience Requirements: Ph.
D. degree in a relevant discipline (such as Biopharmaceutics, Pharmaceutics, Chemical Engineering, or Drug Delivery) with 5+ years of relevant industry experience Required Skills: Good understanding/knowledge of the overall drug development process and knowledge of CMC attributes that define formulation robustness. Relevant industrial experience within drug delivery formulations for nucleic acid delivery (nanoparticle delivery technologies)Practical experience with nanoparticle formulation using various fabrication processes, analytical characterization and accurate data reporting Relevant experience with end-to-end nanoparticle and microparticle production processes for encapsulation of nucleic acids and biologics Flexibility and the ability to adjust to changing priorities and operate in a fast-paced industry environment.
Excellent oral and written communication skills; experience working in multidisciplinary teams Desired Skills: Leadership and stakeholder management skills Ability to navigate ambiguity and synthesize actionable next steps to move programs and strategies forward Track record of scientific competence in terms of publications, presentations and networking activities When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines.
In-person working gives us the platform to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility.
Join us in our unique and ambitious world. " Why Astra Zeneca? At Astra Zeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-medical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together.
Interested? Come and join our journey. So, what's next! Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours. Where can I find out more? Check out our landing page for more information on our BPD group careers. /bpd Our Social Media, Follow Astra Zeneca on Linked In /company/1603/ Follow Astra Zeneca on Facebook /astrazenecacareers/ Follow Astra Zeneca on Instagram /astrazeneca_careers/? hl=en Date Posted 07-Nov-2023 Closing Date Astra Zeneca embraces diversity and equality of opportunity.
We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e. g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.
Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
to the advancement of innovative Cell Therapy products by designing and conducting laboratory experiments, developing methodology, and generating and interpreting scientific data in a highly collaborative environment. Accountabilities: As a Scientist, Bioscience, you will conduct hands-on primary cell culturing, immune functional assays and phenotyping.
You will manipulate and characterize primary cells and cell lines, contribute to experimental plans and designs, backss and report data with high integrity, and communicate results to manager and team members. You will also support a team and work collaboratively with project managers to ensure the efficient relay of information and forward
translation of data. Essential Skills/Experience: BS/MS in a relevant scientific field and 3+ years of research experience in molecular and cellular biology of T and NK lymphocytes, cancer biology, tumor microenvironment, or related field Hands-on experience in the cell culture of established cell lines and/or primary human immune cells Basic expertise on flow cytometry acquisition and analysis In vivo experience with different mouse models Desirable Skills/Experience: Previous experience in the development of CAR-T cells, TCR-T cells, etc.
Familiarity with gene editing techniques (e. g. CRISPR/Cas, viral engineering, base editing, etc. ) Biotechnology or medical industry experience preferred.
Hands-on experience in in vitro NK/T-cell functional characterization including in vitro cytotoxicity assays, proliferation, cytokine measurement.
At Astra Zeneca, we are on a mission to eliminate cancer as a cause of death. As part of our Oncology R&D team, you will be at the forefront of applying science to studies and using innovative approaches to create new possibilities. We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. We lead through true collaboration, building collective wisdom by giving everyone a chance to input. Our commitment to patients and pioneering spirit are truly embedded and it's what makes our pipeline unique.
About Our Gaithersburg Oncology Hub Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration. The Gaithersburg site offers a variety of amenities to help keep our employees happy and healthy.
This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center, game rooms, community garden and more. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. Ready to make a difference? Apply now and join us in our mission to eliminate cancer as a cause of death. Please contact Bobbi Poole, our Talent Acquisition Partner. Closing Date: January 5, 2024 Competitive remuneration and benefits apply We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive.
We have a generous paid time off program and a comprehensive benefits package. Where can I find out more- Our Social Media, Follow Astra Zeneca on Linked In /company/1603/ Follow Astra Zeneca on Facebook /astrazenecacareers/ Follow Astra Zeneca on Instagram /astrazeneca_careers/? hl=en Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.
We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
Please contact us to request accommodation. Date Posted 07-Dec-2023 Closing Date 04-Jan-2024Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e.
g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
and Experimental Medicine (TSEM) department in the Respiratory and Immunology therapeutic area. As a department we promote an open and collaborative atmosphere, with a culture that is both science-based and patient-focused. Our mission is to understand disease mechanisms at the molecular level, identify the most effective targets and the right patient populations.
This role is located at one of our sites in either Gothenburg (Sweden) or Gaithersburg (US). Be encouraged and supported to think creatively in our dynamic environment. Here we are free from fear of failure, free to ask the right questions and make bold decisions. We harness data science & AI to fast-forward our research. Making
sure work born in a lab can make a real difference, every day, impacting patients' lives across the world. What you will do In this role, you will work in a highly cross-functional and thriving environment together with specialists in sequencing, immunological and respiratory disease, as well as with other data science & bioinformatics experts.
For this role we are looking for an outstanding bioinformatician to enable translational science via integration of large-scale omics, clinical data, real world evidence and literature data to deliver precision medicine within our pipeline. Youll be identifying novel targets, biomarkers and patient sub-groups through innovative data analysis approaches
including utilization of clinical cohort omics data sets.
You will contribute to the identification of transformational precision medicine propositions to deliver life changing medicines to patients. You will be responsible for planning, performing and interpreting your analysis and communicate results. By applying state-of-the-art analytical methods, you will maximise the knowledge extrapolated from our growing omics data in complex diseases impacting the project progression and future treatment options for patients with unmet medical needs. Depending on your previous experience, your initial career level will be an Associate Principal Scientist or Senior Scientist.
Essential for the role MSc with extensive industry experience, or preferably, Ph D or equivalent in bioinformatics, data science, statistics, biostatistics, mathematics, or another similar subject area. Experience and proficiency in large-scale omics data analysis, integration and interpretation is a requirement. Omics include transcriptomics, single cell, proteomics (Olink, LC/MS), genomics, and other types of next generation sequencing (NGS) such as chromatin state approaches. Excellent coding skills in Python, R, or similar language appropriate for large scale omics analysis and experience with version control (Git/Bitbucket).
A good understanding of life sciences and how omics data can be utilised to derive biological insight will be a minimum requirement. Experience from applying this across different phases of medical discovery and development is a preference. Outstanding communication and collaboration skills, both with experts and non-experts, and with peers as well as stakeholders is expected. Our team is a collaborative group, so the ability to be comfortable working in a goal-oriented way, with a team focused approach is central to be successful in the role.
We believe you also have a high degree of independence and a proactive and delivery focused approach. Desirable for the role Experience in medical R&D and/or Post-doc experience. Molecular understanding of human diseases, patient stratification and biomarker-based endpoint generation, preferentially in respiratory and immunological disorders. Track record of applying bioinformatic analysis to drive projects in drug discovery or development in an industrial or academic setting. Broad experience applying machine learning methods such as random forests, clustering, dimensionality reduction in a systems biology or systems medicine context.
Working in a Linux environment, ideally with experience of cluster or cloud computing (e. g. AWS or Azure). Experience from leading projects with internal groups/external collaborators. Experience working within cross-functional teams. Why Astra Zeneca? At Astra Zeneca we turn ideas into life changing medicines and strive to continuously meet the unmet needs of patients worldwide. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.
Work policy When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. What's next?
If you are ready to make a difference - apply today, and we'll make it happen together! We welcome your application (including CV and cover letter), no later than January 12, 2024. If you're curious to know more about the position, please get in touch with hiring manager Greet De Baets at xyz X@. Where can I find out more? Follow Astra Zeneca on Linked In: /company/1603/Follow Astra Zeneca on Instagram: /astrazeneca_careers/? hl=en Read more about Biomedicals R&D: /r-d. html Date Posted 20-dec. -2023 Closing Date 19-dec. -2023Our mission is to build an inclusive and equitable environment.
We want people to feel they belong at Astra Zeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
a cure. The Oncology Outcomes Research (O2R) team is composed of high functioning individuals with outstanding strategic, technical and communication skills. The team is a key member of the Evidence Generation and External Alliances Organization within the Global Medical function and develops strategy for and delivers impactful real world, economic and patient reported research for the AZ oncology portfolio.
The mission is to focus on identifying, quantifying, and communicating the medical value proposition of molecules in the oncology portfolio. O2R is a thought partner for the Franchise Leads and an important member of the Global and US Core Medical Team. Activities focus on the generation
of evidence to assist payer and health care provider (HCP) decision-makers and include scientific evidence for reimbursement dossiers and market access.
The deliverables from this team have a significant impact on the success of the global medical strategy. The Senior Scientist is an individual contributor role and will be a crucial member of an Asset team that is collectively responsible for delivering strategic plans and implementing projects. The Senior Scientist reports to the Asset Lead, Oncology Outcomes Research , and will be responsible for leading the execution of health outcomes and real-world strategies and studies on a global and US market level. This role is also responsible
for working with key internal collaborators supporting the execution and communication of studies.
This position requires an individual with scientific knowledge of HEOR and its application throughout development process, business insight, and interpersonal skills. What You'll Do: Responsible for the execution of the Asset strategy for the Oncology Outcomes Research team, and other activities to backss, quantify and communicate the value proposition for the asset. Responsible for specific Global and US Regional health outcomes strategy. Conduct outstanding quality research that is medically relevant, scientifically valid, and aligned with the evidence generation and communication needs.
Will support asset leads and work with outcomes researchers with diverse technical skills. Present research findings at scientific congresses and participate in the development and writing of manuscripts for publication in peer-reviewed journals. Translate output from research into tools and resources for field teams. Manage relationships and budgets with vendors to ensure timely completion of high quality, projects. Maintain in-depth knowledge of the disease state, market & customer dynamics, the competitive landscape, and reimbursement issues Minimum Qualifications: Minimum of 1 year experience, preferably in the medical industry, graduate degree strongly preferred (Ph D, MS, MPH) in health economics, epidemiology, outcomes research and/or related fields.
Understanding and knowledge and application of epidemiological/health outcomes methodology within medical industry at an international level. In-depth expertise with research methods for real world research, HEOR projects including pharmacoepidemiologic models. Demonstrates analytical, judgment and problem-solving skills. Travel-10% Preferred Qualifications: Advanced Scientific degree3 years of HEOR or Outcomes Research experience within industry Standout colleague and supports the asset team within the O2R organization.
Strong written and verbal communication skills as well as interpersonal skills. Next Steps - Apply today! Are you ready to bring new insights and fresh thinking to the table? Brilliant! We have one seat available, and we hope it's yours. Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.
We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. Date Posted 21-Dec-2023 Closing Date Our mission is to build an inclusive and equitable environment. We want people to feel they belong at Astra Zeneca and Alexion, starting with our recruitment process.
We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
be the one for you! About Astra Zeneca At Astra Zeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing.
We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe. As a part of our Biologics Engineering team in Gaithersburg, MD, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives. About Astra Zeneca in Gaithersburg, MD Our Gaithersburg,
Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC.
This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes
a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center.
This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. Summary of the Group The Biologics Engineering department at Astra Zeneca is constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We're utilizing our expertise in protein and antibody engineering to enable novel therapeutic approaches to Oncology, Respiratory, Inflammatory, Cardiovascular and Infectious disease.
We offer a unique and strong collaborative network as part of the Astra Zeneca family, as together we explore new and exciting technologies. The Biologics Engineering group is seeking a creative and talented Senior Scientist to join out Hybridoma team. The successful candidate will have strong background in Immunology/ Cell biology and will be conducting hybridoma campaigns to identify novel antibodies to different therapeutic targets. The applicant will operate independently and in collaboration with other team members and scientists across research to develop our next generation of drugs.
What you will do: As a Senior Scientist within the Hybridoma group, you will design and execute projects from target validation to therapeutic antibody discovery using the hybridoma/B-cell platform Dial in new technologies or improve existing methods to ensure consistent innovation in drug discovery Collaborate and work with different therapeutic teams to drive pipeline progression Interpret data, provide analysis and present data within and across teams Education & Experience Requirements : Ph D degree in Immunology/ Cell Biology or other related field with 0- 2 years postdoctoral or industry experience (preferred)OR Master's degree with 6+ years of relevant experience in industry (preferred) or academia Required Skills : Must have hands-on experience in hybridoma technology, including but not limited to designing experiments, immunogen preparation, animal immunization, cell culture, cell fusion and post-fusion screening.
Experience performing high-throughput screening methods( ELISA, Flow cytometry)Demonstrated experience in optimizing/troubleshooting protocols with a problem-solving mindset. Ability to learn and embrace new technologies quickly, work independently, multi-task and manage shifting priorities Rigorous logical thinking, good communication skills and the ability to work within teams.
Maintain up-to-date knowledge of the latest advances in antibody discovery technologies, and contribute to the development of new and innovative approaches. Excellent organizational skills and data presentation. Desired Skills : Experience with NGS and 10XGenomics for antibody discovery using hybridoma/ B-cell technologies Familiarity with automation and high-throughput screening platforms (e. g. Hamilton, i Que3) Experience with fluorescence activated cell sorting (FACS) for single B cell cloning.
" When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. " Date Posted 05-Dec-2023 Closing Date 30-Dec-2023Astra Zeneca embraces diversity and equality of opportunity.
We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e. g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.
Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
He/She will be a key player in providing high quality, well-characterized proteins to support biologics discovery across multiple therapeutic indications. The successful candidate will be a well-organized and a highly productive scientist that can design and execute experiments efficiently, analyze, interpret, and present data to multidisciplinary project teams.
Astra Zeneca is an exciting company with long-standing tradition of excellence in drug discovery that offers a fantastic culture and great opportunities to enhance your skills and grow your career. At Astra Zeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking
big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.
Responsibilities Perform expression and purification of mono- and multi-specific antibodies and complex modalities fusion proteins from sub-milligram to gram scale to support antibody discovery, characterization, and pre-clinical validation of leads. Perform biologics quality backssment utilizing a variety of techniques, such as CE-SDS, SEC-HPLC, endotoxin assay, etc. Develop and implement purification procedures to improve existing processes and workflows in coordination with BPD. Maintain
and troubleshoot laboratory instrumentation, such as AKTA-Pure, AKTA-Avant, Am Mag, Lab Chip, etc.
Collaborate and work with a diverse group of scientists across all therapeutic areas to ensure timely progress of research projects. Represent BET function on cross-functional teams, providing technical expertise, progress updates and data summaries. Maintain complete and updated records in electronic lab notebook. Required Skills B. S, with 8+, M. S. with 5+ or Ph. D. with 2+ years of experience in Biologics production at Biotech/ Big Pharma Extensive hands-on experience with transient mammalian expression (HEK293 and CHO) and purification of mono- and bi-specific antibodies, Fab fragments, sc Fv, VHH, and various antibody-fusion formats.
Demonstrated proficiency with various modes of chromatography, including affinity, IEX, mixed mode, HIC, and SEC. Deep and current knowledge of resigns, membranes and suppliers. Extensive hands-on experience with chromatography instrumentation (AKTA-Pure, AKTA-Avant, Am Mag) including ability to develop custom methods and troubleshoot. Experience with automation is preferred. Strong protein characterization and QC skills including analytical SEC, CE-SDS, endotoxin assays, etc. Familiarity with molecular biology techniques, including primer design, gene assembly, Gibson and Golden gate cloning, vector assembly, transfection, and software for sequence analysis.
Experience interacting with CMC groups and understanding development upstream and downstream processes, including ultrafiltration, viral clearance, etc. is highly desired. Proven ability to work independently, effectively plan and organize work activities, and prioritize task completion to meet project deadlines in a fast-paced industrial environment. Strong interpersonal and communication skills, ability to collaborate and communicate across disciplines.
About Astra Zeneca in Gaithersburg, MD: Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.
The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees stay happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly designed, activity-based workspaces to suit a variety of working styles while increasing collaboration between teams. " When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions.
That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. " Date Posted 21-Nov-2023 Closing Date 30-Dec-2023Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.
We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e. g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
Astra Zeneca in Gaithersburg, MD Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US.
Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. The Gaithersburg site offers a variety of amenities to help boost productivity and
help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center.
This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. Summary of the Group Biologics Engineering is responsible for the discovery, design, engineering, and optimization of next generation biologics to create biological drug candidates against diseases with improved safety and efficacy. The Multi-specific Engineering Team designs, engineers, and optimizes complex therapeutics through structure-function
principles while collaborating broadly across the AZ Research organization.
We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for the development of in-house biologics discovery platforms and novel drug modalities to address unmet medical needs. Main Duties & Responsibilities Seeking a skilled and highly motivated scientist to enhance our antibody-based platform technology efforts. The successful candidate will be excited by research at the interface where innovative technology meets Biology. Lead collaborative workstreams with a diverse group of scientists across all therapeutic areas to ensure timely progress in research projects and drive technological innovations.
Conceive, design, and execute the engineering of innovative multispecific antibodies with improved selectivity and developability Biochemical, biophysical and functional characterization of antibodies and multispecific modalities Prepare, analyze, and present data internally and externally Education & Experience Requirements Fresh Ph D in Biotechnology, Molecular Biology, Biochemistry or other relevant scientific field. Required Skills Extensive hands-on experience in molecular biology and antibody engineering, including; design, expression, purification and biochemical/biophysical characterization of various bispecific antibody formats Proven ability to work independently, effectively plan and organize work activities and prioritize task completion to meet project deadlines Deep understanding of various imaging/multicolor flow cytometry-based instruments and data analysis programs Comprehensive experience in tissue culture techniques and functional cell-based assay development Demonstrated experience in optimizing/troubleshooting protocols with a problem-solving mindset Track record of scientific innovation as evidenced by scientific publications, patents and oral presentations at conferences Desired Skills and experience: 2+ years of post-doctoral experience in antibody engineering and/or bispecific antibody technologies.
Understanding of protein structure-function relationships and antibody structural remodeling Experience in engineering antibodies with improved properties (e. g. affinity, solubility, and other attributes related to developability)Background in antibody discovery using one of several display-based technologies Working knowledge of automation and high-throughput screening from bacterial or mammalian expression systeminteractionperience in immunocytokine and T-cell engager Excellent written and verbal communication skills and effective presentation of complex scientific data to cross-functional and senior management Date Posted 09-Nov-2023 Closing Date 30-Dec-2023Astra Zeneca embraces diversity and equality of opportunity.
We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be.
We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e. g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
Analytics division is a group of experts from different disciplines including Data Science, Real World Evidence and Bioinformatics who are focused on applying their skills to advance and transform the drug discovery process at Astra Zeneca. We collaborate deeply across all therapeutic areas and work closely with our leading biologists, chemists to try and address how big data can accelerate our drug development pipelines.
In particular, this role will focus on collaborating with AZ's Biologics Engineering group who are developing and productionizing a transformational AI driven high throughput antibody discovery platform using Illumina NGS technology. If you want to have an impact on
transforming patients' lives by accelerating new medicines to patients, this may be the position for you! We are looking for a Bioinformatics Scientist to join our translational Bioinformatics team.
What You'll Do: Contribute to the development of an end-to-end data analysis capability as part of a cross-functional team Evaluation of new NGS technologies Work collaboratively with data and drug discovery scientists to establish primary and secondary analytics workflows on new systems for biologics discovery Support testing and verification of data management analyses and tools and pipelines in collaboration with AZ stakeholders Demonstrate effective communication to translate complex concepts
to non-experts in internal and external scientific meetings Contribute ideas and provide creative input to projects across multiple disease areas including respiratory, immunology, cardiovascular, renal, metabolism and neuroscience.
Remain at the cutting edge of bioinformatics. Essential for the Role: Ph D in bioinformatics or related field and 3+ years relevant experience Experience in using and analysing illumina NGS data Demonstrated ability to apply data analysis methods to large datasets Experience with Python Ability to explore novel bioinformatic approaches to improve sensitivity and specificity of NGS based workflows. Strong, professional communication skills and excellent attention to detail, capable of developing good working relationships with diverse individuals Experience working within a team environment Takes ownership of tasks and has a can do attitude Desirable for the Role: Experience in illumina workflows, in particular the primary analysis around going from raw images to fastq files Experience with R, bash or Rust programming languages Experience with Kubernetes cluster and associated software e.
g. kubeflow First-hand experience in the analysis and interpretation of large, complex datasets. Experience with create production quality code and software engineering techniques and practices.
e. g. version control, Jira, Agile, Scrum, code reviews etc. Familiarity with multiple R&D data types, especially as they relate to therapeutic area research. Capability of successfully managing multiple simultaneous projects Date Posted 20-Dec-2023 Closing Date 19-Jan-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at Astra Zeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics.
We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person. About Astra Zeneca in Gaithersburg, MD: Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world.
This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees
benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy.
This includes a fitness centre, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria, and copy centre. This is where you'll find newly designed, activity-based workspaces to suit a variety of working styles while increasing collaboration between teams. Astra Zeneca has an opportunity for a Scientist in the Physicochemical Development Group within the Analytical Sciences Department in Gaithersburg,
MD. Summary of the group In the Analytical Sciences group, you'll play a pivotal role in channelling our scientific capabilities to make a positive impact on changing patients' lives.
We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We're pioneering innovative research and exploring novel pathways across key therapeutic areas including oncology, respiratory, inflammation and autoimmunity, cardiovascular and metabolic disease, and infection and vaccines. And we're industry-leading in immunology, protein engineering and translational science. We offer a unique and strong collaborative network as part of the Astra Zeneca family.
Major Duties and Responsibilities : The successful candidate will be responsible for developing, troubleshooting, and/or executing assays using Chromatography, Electrophoresis, and/or Mass Spectrometry techniques in supporting development, manufacturing, and characterization of biomedical products, such as humanized monoclonal antibodies, antibody-drug conjugates, and recombinant proteins. The candidate will be expected to make detailed experimental observations, review and analyze data, and interpret experimental results, and summarize data for presentations and reports.
The candidate will have opportunity to author/revise SOPs, protocols, technical reports and other relevant documentation. Requirements/Qualifications : Hands on experience on chromatography (SEC, IEC, RPLC, GC), and/or electrophoresis (c IEF, CE-SDS). Relevant industry working experience as well as a background in protein chemistry. Great teamwork and communication skills, both verbal and written, are critical. Good multi-tasking, time management and organizational skills are required. essential. The ability to follow SOPs, policies, and regulations, and to perform routine lab equipment maintenance is required.
Ability to work in a team environment, attention to detail and strong verbal and written communication skills are also necessary. Experience with glycan and peptide mapping analysis is a plus. Education/Experience : Scientist: BS degree with 5+ years or MS with 2+ years of laboratory experience Special Skills/Abilities : Familiarity with data analysis software such as Empower and Open Lab When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions.
That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. " Why Astra Zeneca? At Astra Zeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential.
Join us on our journey of building a new kind of organisation to reset expectations of what a bio-medical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey. So, what's next! Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours. Where can I find out more? Our Social Media, Follow Astra Zeneca on Linked In /company/1603/ Follow Astra Zeneca on Facebook /astrazenecacareers/ Date Posted 06-Dec-2023 Closing Date Astra Zeneca embraces diversity and equality of opportunity.
We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e. g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status).
We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
Astra Zeneca in Gaithersburg, MD: Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US.
Here, we play host to some of the most innovative technology and lab spaces, all designed to inspire collaboration and multi-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. The Gaithersburg site offers a variety of amenities to help boost productivity and help
keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center.
This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. Summary of the group: The Bioprocess Technologies and Engineering team is working to develop and apply new technologies to manufacture life-changing biologics in multiple therapeutic areas. As a cell culture scientist in Bioprocess Technologies and Engineering (BTE), you will join a team developing Astra Zeneca's Next Generation Manufacturing platform,
where we use engineering and science to understand and tackle problems.
Our team works with bioreactors and genetically modified Chinese hamster ovary cells to produce new drugs, and are developing new methods to improve productivity and product quality, so that we can provide our medicines to patients around the world. Main Duties & Responsibilities: This position within the Bioprocess Technologies and Engineering team involves working multi-functionally with the Cell Line Development and Engineering team, to develop new procedures and methods to improve the engineering and identification of production cell lines suitable for the Next Generation Manufacturing process.
You will be developing strategies and transferring knowledge to other development scientists. Additionally, you will be leading and advising scientists in adjacent groups on best practices. Application of perfusion and continuous processes to gene and cell therapies are also possible. Major responsibilities include: Developing next generation mammalian clone screening processes, including cell culture consistency and performance, conduct cell culture experiments from transfection and expansion to the characterization of stable cell lines with high efficiency assays Supporting the Platform Continuous Cell Culture and Purification teams as well as the Platform Cell Line Development teams Writing work guides and SOPs to instruct other scientists on the best practice methods Collaborating with colleagues to augment existing in-process analytical systems and data historians Building or applying mathematical models that predict cell biology Developing automation methods that control the cell culture process Demonstrating leadership in science and technology Demonstrating ability to train peers in novel bioprocessing methods Presenting at internal departmental and multi-functional meetings, and may participate/present at external meetings Ensure that work is performed in accordance with Safety, Health and Environment regulations and Astra Zeneca best practices Education & Experience Requirements: Degree in STEM related fields including biochemical engineering, biochemistry, cell biology, genetics, molecular biology, and biological sciences Bachelor's degree or MS with 0+ years of related experience in industry or academia Required Skills: Aseptic technique Basic molecular biology and cloning techniques, including vector construction and PCR Experience with data and statistical analysis Problem solving and scientific reasoning Ability to work independently Ability to lead development projects Strong communication skills with peers and management Effective planning and organization skills High level of attention to detail and ability to independently solve scientific and technical problems Desired Skills: Suspension cell culture experience Analytical techniques such as titer and product quality analysis and flow cytometry Experience with robotics and high-throughput processes Programming in Python, Mat Lab, R, or other scientific language Fundamental understanding of field of scientific study Why Astra Zeneca?
We are proud to work for Astra Zeneca for many reasons. Most recently, we are proud of our development of a vaccine and antibodies to treat or prevent COVID19. During the pandemic, we have pledged to forgo any profit from these products! And we are making these products available globally! We are working incredibly hard on these and other projects, and need you to join us so we can be successful. Astra Zeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big.
Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-medical company can be. This means we're opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together. Interested? Come and join our journey. So, what's next! Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours. Where can I find out more? Check out our landing page for more information on our BPD group careers.
/bpd Our Social Media, Follow Astra Zeneca on Linked In /company/1603/ Follow Astra Zeneca on Facebook /astrazenecacareers/ Follow Astra Zeneca on Instagram /astrazeneca_careers/? hl=en Date Posted 21-Nov-2023 Closing Date Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be.
We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e. g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person. About Astra Zeneca in Gaithersburg, MD: Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world.
This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees
benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy.
This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. Summary of the group: The m RNA Drug Product Development Team is a part of the Dosage Form Design and Development group of Biomedical Development.
The team's purpose is to advance the development of m RNA products and processes, including manufacturing of lipid nanoparticles (LNPs) to deliver life-changing vaccines and medicines to our patients.
This purpose is realized through an application of a wide range of scientific disciplines converging to bridge between formulation and device capabilities and providing leadership from early research through CMC activities for m RNA delivery technologies. Areas of focus include: Strong collaboration with medical Sciences Advanced Drug Delivery team to enable identification and selection of appropriate lipids and LNP composition for downstream development activities Lead CMC activities across Dosage Form Design and Development to enable optimization of RNA-LNPs to a platform state Identification of new technologies to employ for product and process understanding Identification and initiation of key collaborations to advance m RNA-LNP platform development and product understanding Strategic insight for Technology Development in Dosage Form Design and Development Main Duties & Responsibilities: Serve as a key collaborator and partner for advancement of lipid selection and LNP composition with internal Advanced Drug Delivery team Serve as a CMC DP activity leader for Astra Zeneca nucleic acid programs providing oversight and execution of all elements of CMC delivery post Lead Optimization through clinical trials.
Lead the development of customized drug delivery formulations for non-viral delivery of various nucleic acids to support several therapeutic areas Provide technical expertise, design and execute experiments, analyze and present experimental data and sound recommendations Act as SME in project teams and across the organization Identification and evaluation of external technologies to support advancement of Astra Zeneca's internal m RNA-LNP manufacturing platform Education & Experience Requirements: Ph.
D. degree in a relevant discipline (such as Biopharmaceutics, Pharmaceutics, Chemical Engineering, or Drug Delivery) with 8+ years of experience in relevant work Required Skills: Good understanding/knowledge of the overall drug development process and knowledge of CMC attributes that define formulation robustness. Relevant industrial experience within drug delivery formulations for nucleic acid delivery (nanoparticle delivery technologies)Practical experience with nanoparticle formulation using various fabrication processes, analytical characterization and accurate data reporting Relevant experience with end-to-end nanoparticle and microparticle production processes for encapsulation of nucleic acids and biologics Flexibility and the ability to adjust to changing priorities and operate in a fast-paced industry environment.
Excellent oral and written communication skills; experience working in multidisciplinary teams Desired Skills: Leadership and stakeholder management skills Ability to navigate ambiguity and synthesize actionable next steps to move programs and strategies forward Track record of scientific competence in terms of publications, presentations and networking activities When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines.
In-person working gives us the platform to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. " Why Astra Zeneca? At Astra Zeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big.
Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-medical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey. So, what's next! Are you ready to bring new ideas and fresh thinking to the table?
Brilliant! We have one seat available and we hope it's yours. Where can I find out more? Check out our landing page for more information on our BPD group careers. /bpd Our Social Media, Follow Astra Zeneca on Linked In /company/1603/ Follow Astra Zeneca on Facebook /astrazenecacareers/ Follow Astra Zeneca on Instagram /astrazeneca_careers/? hl=en Date Posted 07-Nov-2023 Closing Date Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills.
We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e. g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
Inflammatory, Cardiovascular and Infectious disease. We offer a unique and strong collaborative network as part of the Astra Zeneca family, as together we explore new and exciting technologies. This opportunity The Discovery Innovation group within BE in Gaithersburg, MD is seeking a talented and highly motivated Scientist to support antibody discovery using a novel microfluidics-based antibody discovery engine.
The candidate will operate with a diverse group of scientists to deliver the pipeline and develop the platform for improved speed, potency and robustness. We are seeking a candidate with expertise in antibody library generation and high-throughput screening that is excited by
research at the interface between technology and biology. The selected individual will be a well-organized and a highly productive bench scientist that can design and execute experiments efficiently, as well as analyze, interpret and present data to multidisciplinary project teams.
Required Education/Experience B. S. in molecular biology or other related discipline with 5+ years experience, preferably in industry OR M. S. in molecular biology or other related discipline with 2+ years experience, preferably in industry Main Job Responsibilities Generate high quality antibody libraries for phage, yeast or mammalian display. Design and implement high-throughput automated screening assays
for antibody characterization (e. g. ELISA, DELFIA, or HTRF). Interface with automation team to implement and optimize processes (e.
g. colony picking, cherry-picking, and sequencing). Perform Molecular Biology techniques for antibody cloning and production. Required skills Demonstrated and extensive experience in building highly complex antibody libraries used to isolate candidate binders with automation. Use of advanced PCR techniques (e. g. multiplex, dd PCR, emulsion PCR) applied to dozens of samples. Expertise in high-throughput (96-well) assays for antibody characterization and quantification, such as ELISA, BLI, high-throughput flow cytometry. Proven experience to troubleshoot, optimize and execute experiments independently.
Desired skills Experience with high-throughput mammalian cell DNA transfection Experience with cell staining and sorting (FACS)Experience with Next Generation Sequencing (library preparation, sample loading, and sequence analysis) Special Skills / Abilities / Knowledge / Behavioral Competencies Strong communication skills are highly desirable. The individual should also be self-motivated, embrace new technologies and have demonstrated an ability to work in teams. Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world.
This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy.
This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams. " When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office.
But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. " Date Posted 15-Nov-2023 Closing Date 30-Dec-2023Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e.
g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
This role will develop and implement patient-facing marketing plans that incorporate consumer interaction as well as those provided through nurses, and will work with cross functional partners to develop robust market shaping activities for commercial success.
This position is based at our Gaithersburg, MD campus (Washington DC Metro area) at our Oncology Business Unit headquarters. Key Accountabilities: Develop the consumer & nurse marketing strategy, tactical planning, and execution Translate the brand science and strategy into consumer-friendly terms in an effort to make a positive impact on patient's lives - either directly or through nursing materials Establish consumer marketing
critical metrics including multi-channel media measurement and analytics plans Lead development of CRM strategy and program development for patients Lead creation and delivery of core consumer assets in close collaboration with key cross-functional partners such as Business Insights and Analytics, Corporate Affairs, Payer Access Strategy, Brand Team Build the social media strategy Lead partner agency relationships, workflow and related expense budgets Ensure legal/regulatory compliance and medical accuracy of all marketing materials Qualifications: Minimum qualifications Bachelor's Degree in relevant field Prior commercial experience with consumer or HCP marketing8 years' confirmed experience
in medical and/or healthcare industry with experience in one or more of the following: consumer marketing, HCP marketing, new product planning, brand marketing, sales, or market research/analytics Oncology experience Ability to lead team of cross functional and technical members to achieve outcomes Strong eye for business, as role is responsible for leading multiple program budgets, timelines, process and procedures Preferred qualifications Advanced degree (Master's or higher) in Life Science, MBA, Medical, or shop Experience in nurse marketing / education, consumer marketing Experience across multiple promotional channels (Personal, Non-Personal and Digital, Patient marketing)Management, launch and customer facing experience Why Astra Zeneca?
At Astra Zeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Next Steps -- Apply today! To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience -- it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.
Date Posted 20-Oct-2023 Closing Date 19-Jan-2024Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e. g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status).
We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.
exceptional skills with those of people from all over the globe. The Oncology therapy area at Astra Zeneca is unparalleled. We have built and strategically acquired one of the most promising Oncology pipelines in the industry. You will be among inspiring oncology industry leaders who will keep you engaged and empower you to be the best.
We seek out opportunities to do dynamic and significant work which means we won't just follow the same course of action time and again if we can see potential in a different way of building life changing medicine. We share a collective sense of urgency - to defeat cancer and improve the lives of cancer patients. In addition to being one of the world's
leading medical companies, Astra Zeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. Within this environment employees are empowered to express diverse perspectives, and are made to feel valued, energized and rewarded for their ideas and creativity.
One of the most exciting and fastest growing Oncology portfolio worldwide One of the strongest Oncology pipelines in the industry Well poised to become a world leader in several areas of oncology, with established and emerging blockbuster brands Progressive company, diverse and inclusive We live by our values Highest visibility in the organization and externally The Senior Manager,
Consumer Marketing, Oncology (DDR) will be responsible for the strategic planning and tactical execution for our consumer marketing plans.
This individual will be responsible for providing Astra Zeneca leadership required to drive and deliver on the consumer brand strategy for all tumors: Ovarian, Breast Cancer, Prostate, and Pancreatic, and including any pan-tumor consumer initiatives. Consumer activities will be implemented in close partnership with Alliance partners, who are leading Direct-to-Consumer across all tumor types. Key areas of focus for this role include the following: digital strategy, integration with HCP marketing, understanding key consumer and market insights, developing a comprehensive strategy and tactics with clear performance metrics.
This position will report directly into the Director, Oncology Marketing, Pan-tumor, and will work in close partnership with marketing colleagues across the entire team. The role will work across the DNA Damage Response (DDR) Franchise and the Oncology Business Unit and will play a meaningful role in integrating the execution of our marketing plans across indications. This position is based at our Gaithersburg, MD campus, headquarters. Key Accountabilities: Develop digital and consumer/patient marketing strategy and tactical planning Facilitate development and execution of patient promotional plan and programs, ensure alignment with brand strategy Facilitate development and execution of unbranded initiatives to support patient/caregiver education Translate the brand science and strategy into consumer-friendly terms in an effort to make a positive impact on patients' lives Collaborate on direct-to-consumer strategy and execution for the Business Strategy Planning annual process, across tumors Establish consumer marketing critical metrics Develop or evolve CRM strategy and program execution for patients across tumors Build alliances with internal team members such as Business Insights and Analytics, Corporate Affairs, Brand Team, Payer Access Strategy members to help with cross-functional planning and to ensure a strong, evidence-based approach to support the delivery of consumer materials Partner closely with agency and to ensure efficient delivery of consumer deliverables, including efficient workflows and impactful, insights-driven content Ensure legal/regulatory compliance and medical accuracy of all marketing materials Qualifications Minimum of Bachelor's Degree3-5 years of commercial experience with consumer or HCP marketing experience in medical and/or healthcare industry with experience in one or more of the following: consumer marketing, HCP marketing, new product planning, brand marketing, sales, or market research/analytics, strategic planning Preferred qualifications MBAOncology, rare disease or specialty care experience highly preferred Understanding of U.
S. Oncology landscape including Community Oncology and Hospital Oncology dynamics, GPOs, Payer landscape, Specialty shop partners Marketing experience (developing brand strategy, performing positioning, messaging, segmentation, targeting, leading ad agency, providing direction on annual budget planning)Experience across multiple promotional channels (Personal, Non-Personal and Digital, Patient marketing)Launch experience Skills Excellent communication skills (verbal and written)Confirmed collaboration skills - internal, cross-functional, and external Demonstrated strategic thinking skills Ability to lead sophisticated projects and remain focused in ambiguity Proven ability to lead without authority Ability to gauge the feasibility, impact and risks of proposed programs Comfort operating in a highly regulated environment and industry Possess strong eye for business skills, as role is responsible for prioritizing multiple programs across tumors, timelines, process and procedures, and being a steward of the consumer budgets High ethical standards and personal integrity When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines.
In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible.
We balance the expectation of being in the office while respecting individual flexibility. Join us in our outstanding and daring world. Next Steps -- Apply today! Are you ready to bring new insights and fresh thinking to the table? Brilliant! We have one seat available, and we hope it's yours. To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience -- it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.
Date Posted 21-Dec-2023 Closing Date 27-Dec-2023Our mission is to build an inclusive and equitable environment. We want people to feel they belong at Astra Zeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.