of my knowledge. Job Description About the role: At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.
The vision of Takeda is to build a world-class Cell Therapy team and deliver allogeneic innate cell therapy product to bring hope to both hematological and solid tumor patients. Oncology Cell Therapy Innovation is missioned to develop innovate innate cell platform and novel engineering approaches to drive discovery
pipeline for Takeda Cell Therapy The Oncology Cell therapy Innovation team is seeking experienced molecular biologist who has a background in cancer immunology, genetic engineering especially non-viral mediated gene editing.
As a senior member of the team, you will play an important role in optimizing cell therapy platforms, e. g. CAR-NK, CAR-γδ T, to improve the biological function (potency and persistence) of cell therapy products, based on solid understanding of innate cell biology, cancer/immune biology in tumor microenvironment and genetic engineering. You will lead discovery projects and collaborate with colleagues within department and cross-function teams to drive the development
of Cell Therapy discovery platforms. How you will contribute: Contribute to discovery projects by independently designing and developing well-defined mechanistic experiments and projects within oncology cell therapy research.
Lead from the lab to advance novel and differentiated cell therapy products toward clinical milestones, by working collaboratively with internal cross-functional teams and external partners. Design, execute, and interpret functional in vivo, in vitro, and ex vivo assays to understand the mechanism-of-action and play an active role in subsequent scientific discussions to drive decisions. Propose novel projects based on internal results, external partners, and published reports and demonstrate leadership through communication of study plans/value, and research results Skill and breadth of knowledge in a scientific field Stay current with scientific development (e.
petitive landscape, new technology, new research portfolio, and new partnership) Scientific leadership and establish rigorous standards for execution effectiveness Have managerial responsibility Independently control workload and demands Scientifically independent Scientific driver for research strategy that impacts group internally and outside area of function Initiate and lead external interactions and collaborations Frequent contact with internal and external personnel at multiple management levels Elect approaches for new tasks and provide strategic project recommendations Minimum Requirements/Qualifications: Ph.
D. in Immunology, Biology, Genetic Engineering, or related discipline. Minimum of 6+ years relevant medical industry/academic experience post-graduation Hands on experience with CRISPR-, transposon-mediated genome engineering in multiple cell types. Independently design sg RNAs, constructs for KO and KI through non-viral (plasmid, self-replicating vectors, EP, LNP) methods.
Profound skills in analytical methods such as flow cytometry, dd PCR, real-time PCR, off-targets evaluation, NGS etc. Previous experience with CAR-T, CAR-NK, CAR-γδ T, TCR-T cell immunotherapies, including cell culture, immune cell activation/expansion, viral transduction in vitro and in vivo immune cell characterization and function backssment, such as, multi-color flow immunophenotype, multiplex cytokine measurement, cytotoxicity assay is a plus Excellent written and verbal communication skills, detail-oriented organization skills, and team collaboration skills.
Track record of publications to demonstrate scientific establishment. What Takeda can offer you: Comprehensive Healthcare: Medical, Dental, and Vision Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan Health & Wellness programs including onsite flu shots and health screenings Generous time off for vacation and the option to purchase additional vacation days Community Outreach Programs and company match of charitable contributions Family Planning Support Flexible Ways of Working Tuition reimbursement More about us: At Takeda, we are transforming patient care through the development of novel specialty medicals and best in class patient support programs.
Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work. Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.
EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations Boston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time
of my knowledge. Job Description Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Senior Scientist / Principal Scientist, Oncology Cell Therapy Innovation in our Cambridge, MA office.
At Takeda, we are transforming the medical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united
by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Here, you will be a vital contributor to our inspiring, bold mission.
The vision of Takeda is to build a world-class Cell Therapy team and deliver allogeneic innate cell therapy products to bring hope to both hematological and solid tumor patients. Oncology Cell Therapy Innovation is missioned to develop innovate innate cell platforms and novel engineering approaches to drive the discovery pipeline for Takeda Cell Therapy. ROLE OVERVIEW: This position is seeking an experienced and highly motivated immunologist, who has a solid background in immunology, especially immuno-oncology and
innate cell biology, to join the Cell Therapy Experimental Immunology team.
We are looking for someone who is highly dedicated and driven to advance new therapies to patients and who has a strong work ethic, drive and collaborative mindset. The candidate will lead efforts in identifying new ways to optimize CAR-NK and CAR-γδ T cell platforms byimproving our understanding of the basic biology of NK and γδ T cells. The focus will be in discovering new ways to improve potency, persistence and immune modulation through developing a solid understanding of activation, survival, costimulation, differentiation, and suppressive mechanisms affecting these cells. The principal scientist will lead discovery projects and collaborate with colleagues within and across departments.
How you will contribute: Contribute to pre-clinical/discovery work by designing, executing and leading experiments to further understand key pathways and mechanisms driving NK and γδ T cells biology Lead from the lab to advance novel and differentiated cell therapy products toward clinical milestones, by working collaboratively with internal cross-functional teams and external partners. Design, execute, and interpret functional in vivo, in vitro, and ex vivo assays to understand the mechanism-of-action and play an active role in subsequent scientific discussions to drive decisions.
Propose novel projects based on internal results, external partners, and published reports and demonstrate leadership through effective communication of study plans/value, and research results. Prepare and present comprehensive technical or project reports and formal presentations/posters to full range of internal/external audiences. Ability to work independently and prioritize work in a fast-paced environment. Maintain laboratory notebooks and follow laboratory practices in compliance. Contribute to IND report and documentation.
Collaborate with cross-function teams and contribute in matrix-based project groups Other job duties as assigned. Minimum Requirements/Qualifications: Ph D degree in a scientific discipline with 6+ years experience, or MS with 12+ years experience, or BS with 14+ years experience Minimum of 8+ years relevant medical industry/academic experience post-graduation Hands-on experience with CAR-T, CAR-NK, CAR-γδ T, or TCR-T cell therapies/immunotherapies is required, including cell culture, immune cell activation/expansion, cytotoxicity assays, sc RNAseq and high-throughput screening.
Profound skills in in vitro and in vivo immune cell characterization and functional backssment, such as, multi-color flow immunophenotyping, multiplex cytokine measurements, cytotoxicity assays, and other molecular based assays. Experience with lentiviral transduction/CRISPR mediated KO/KI. Excellent written and verbal communication skills, detail-oriented organization skills, and team collaboration skills. Track record of publications to demonstrate scientific establishment. What Takeda can offer you: Comprehensive Healthcare: Medical, Dental, and Vision Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan Health & Wellness programs including onsite flu shots and health screenings Generous time off for vacation and the option to purchase additional vacation days Community Outreach Programs and company match of charitable contributions Family Planning Support Flexible Ways of Working Tuition reimbursement More about us: At Takeda, we are transforming patient care through the development of novel specialty medicals and best in class patient support programs.
Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.
Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply. #LI-AA1 EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations Boston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time
