of my knowledge. Job Description About the role: At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.
Join Takeda as a Biomarker Scientist II where you will have a good scientific background in liver fibrosis and/or metabolic dis-eases with experience in biomarker identification and development. You will be will be responsible for biomarker discovery and validation efforts for novel targets and drug candidates
and independently or collaboratively design and implement extensive biomarker research strategies to support multiple projects in collaboration with internal research teams, external partners and/or CROs.
As part of the Liver Disease Research team, you will report to the Associate Scientific Director and work with the Gastroenterology Drug Discovery Unit (GI DDU). How you will contribute: Develop and implement new biomarker concepts for the treatment of liver fibrosis and other chronic liver diseases. This includes biomarker identification, development and validation etc. Develop and oversee novel scientific biomarker projects in collaboration with internal and external partners. Establishes
project direction integrating science, key technical knowledge, and program objectives.
Perform lab bench work on target and drug candidate discovery, validation and mechanism of action studies using contemporary in vitro/ in vivo methods and tools. Participate on cross-functional teams and provide technical leadership in area of expertise. Proactively identify complex obstacles to progress in specific areas; recommend and implement solutions using a diverse set of resources; regularly add value to research projects through creative ideas. Prepare technical reports, summaries and quantitative analyses in written and/or oral form. Communicate with colleagues effectively.
Present data to other scientific staff or cross-functional project team; may present data/posters to external research or scientific community and publish research results as appropriate. Act as a biomarker lead to be involved in different stages of portfolio projects to provide input and contribute to Go or No Go decisions for various milestones. Performs as a role model supporting Takeda culture and follow policies. Minimum Requirements/Qualifications: Ph. D. degree in biology, cardio/metabolic diseases, or immunology or molecular pharmacology with relevant post-doc experience with 2+ years of experience, or MS with 8+ years of experience, or BS with 10+ years' experience.
Previous experience in NASH/chronic liver disease or fibrotic diseases or understanding of liver disease pathogenesis and pre-clinical therapeutic mechanisms of action research. Demonstrated ability to independently design and solve scientific problems using multiple, state-of-the-art technologies, experimental methods, and approaches is required. Previous experience in relevant protein and RNA-based assays as well as use of multiomic approaches for biomarker discovery, validation or development is preferred.
Previous experience and lab skills to address various types of biomarkers, modalities, and matrices, across animal models and human samples is preferred. Previous experience with translational biomarker research and working experience with clinical samples is preferred. Previous experience of using Omics platforms and collaboration with computational biologists. Good project management experience with a good understanding in various scientific disciplines in drug discovery (toxicology, DMPK, pharmacology etc. ) is a plus. Demonstrated track record by publications in scientific journals.
Good communication skills (oral, written, and presentation) and a good team player. What Takeda can offer you: Comprehensive Healthcare: Medical, Dental, and Vision Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan Health & Wellness programs including onsite flu shots and health screenings Generous time off for vacation and the option to purchase additional vacation days Community Outreach Programs and company match of charitable contributions Family Planning Support Flexible Ways of Working Tuition reimbursement More about us: At Takeda, we are transforming patient care through the development of novel specialty medicals and best in class patient support programs.
Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work. Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Base Salary Range: $130,200.00 to $186,000.00, based on candidate professional experience level.
Employees may also be eligible for Short-term and Long-Term Incentive benefits as well. Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off. The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience. In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.
#LI-SB1#LI-Onsite EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations San Diego, CA Worker Type Employee Worker Sub-Type Regular Time Type Full time
and biological scientists to perform translational oncology research around multimodal translational data sets for programs in clinical development. For this position, we are seeking a demonstrated scientific leader with a consistent and outstanding record of creativity and performance in multimodal data integration and analysis for cancer biology R&D, evidenced by peer reviewed publications in top tier journals, patent applications, and/or publicly available code repository.
As a Principal AI Scientist, you are expected to: Lead advanced machine learning and analytical method application to extract disease biology insights and support innovative clinical development programs and publications
on multimodal translational data sets that include single cell and spatial 'omics, RNAseq, ct DNA, digital pathology, and clinical data. Actively and collaboratively promote scientific and technical innovation with other members of the Department.
Direct and support publications in high quality scientific, technical or medical journals. Represent the department and translational teams externally through interactions with our key computational collaborators. Interact with key partners and investigators and effectively manage internal and external scientific collaborations. Participate and thrive in an interactive, collaborative, and team-oriented culture. Who You Are Ph D degree in a relevant
field (e. puter science, computational biology, bioinformatics, molecular biology, cancer biology, genomics).
Minimum of 3 years post-Ph D experience, with demonstrated scientific leadership in integrating, analyzing, and interpreting multimodal biological data in an academic and/or industry setting. Fluency with Python and data analysis using modern frameworks for deep learning (e. g. Pytorch, Tensor Flow-Keras). Experience with RNAseq data, systems biology tools, and pathway analysis. Excellent communication and collaboration skills. Experience with image analysis methods, particularly around spatial biology, is desirable. The expected salary range for this position based on the primary location of South San Francisco, CA is $165,600- $307,500.
Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits#g CSGenentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, interactionual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
vivo experiments using tumor and autoimmune mouse models. As a member of our team, you will apply innovative technologies to address pertinent questions in cancer immunology and autoimmunity. Please see our relevant published work: Waite JC et al. Sci. Transl.
Med. (2020). DOI: 10.1126/scitranslmed. aba2325Skokos D et al. Sci. Transl. Med. (2020). DOI: 10.1126/scitranslmed. aaw7888As a Scientist in the Cancer Immunology team, a typical day might include the following: Planing and executing in vivo studies using mice with induced or spontaneous tumor and autoimmune disease models. Performing injections through various routes (intraperitoneal, intravenous, subcutaneous). Collecting blood
and isolating mouse tissues. Isolating immune cells from mouse and human tissues for further functional and phenotypic characterization. Performing ex-vivo immunophenotyping using multicolor flow cytometry.
Designing and executing in vitro cell-based functional assays using primary or engineered cells (molecular biology assays such as ELISA/MSD, ELISPOT, RT-PCR, flow cytometry, immune cell proliferation/cytotoxicity assay and immunofluorescence imaging). Maintaining and culturing cells as necessary. Analyzing data using Flow Jo, Microsoft Excel and Graph Pad Prism. Developing new methods or technologies, and troubleshoot experiments. Write protocols and study reports, produce, and maintain
accurate electronic records. Communicate findings to peers and management at various group and cross functional meetings.
This role might be for you if you: Enjoy working in a fast-paced environment. Learn quickly and have desire to expand your skill set with new techniques. Are detail oriented, well-organized and can multi-task effectively. Are a team player with a collaborative spirit. You have strong communication skills. To be considered for this opportunity you must have a Bachelor's or Master's degree in Immunology, Bioengineering or related fields with at least 4 years of experience working in an immunology or cancer biology laboratory. Experience conducting experiments using mouse models with training in proper handling and care of mice.
Experience in tissue culture and cell-based assays, including flow cytometry. Proficient computer skills and experience collecting and analyzing biological data. Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process.
Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U. S. If you are outside the U. S, please speak with your recruiter about salaries and benefits in your location. Salary Range (annually) $88,500.00 - $144,500.00
and executing a variety of cell-based immunological assays and in vivo experiments using tumor and autoimmune mouse models. This role will employ industry-leading technologies to address pertinent questions in cancer immunology and autoimmunity. Please see our relevant published work: Waite JC et al.
Sci. Transl. Med. (2020). DOI: 10.1126/scitranslmed. aba2325Skokos D et al. Sci. Transl. Med. (2020). DOI: 10.1126/scitranslmed. aaw7888As a Principal Scientist in the Cancer Immunology team, a typical day might include the following: Developing, optimizing, and performing various immunoassays to evaluate therapeutic candidates' impact on immune cell function and phenotype, including advanced
techniques such as multicolor flow cytometry and fluorescence microscopy. Independently planning and executing in vivo studies using tumor and autoimmune mouse models.
These will include treatments with injections through various routes (IP, IV, SC), blood and tissue collection for downstream analysis of immune responses. Analyzing data using biological and statistical software such as OMIQ, Prism, Excel, etc. Collaborating with cross-functional scientists to drive target validation and therapeutic antibody development. Delivering impactful presentations to colleagues across our business, including senior leadership. Writing protocols and study reports, maintaining accurate electronic
records. Routinely reviewing relevant literature, attending scientific meetings, and improving expertise in the field of Immunology and Immuno-Oncology.
Training and management of research associates as needed. This role might be for you if you: Get excited about developing immunotherapies that promote a tumor-specific and durable immune response to eradicate cancer for patients. Have a passion for innovation and desire to lead new scientific directions. Are a team player with a collaborative spirit. Possess excellent communication, organization, and time management skills. Independently design and execute experiments, analyze data, and interpret results. Are confident with multitasking and managing multiple projects simultaneously.
This role requires a Ph. D. in immunology, immuno-oncology, or a related field, 5+ years of relevant industry and/or academic related experience, and a strong record of innovation and publications. Proven expertise in T cell biology with experience using mouse tumor and autoimmune models, including high dimensional immunophenotyping, is required. Proficiency with fluorescence microscopy and advanced imaging techniques is a plus. Does this sound like you? Apply now to take your first steps toward living the Regeneron Way!
We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U.
S. If you are outside the U. S, please speak with your recruiter about salaries and benefits in your location. Salary Range (annually) $121,200.00 - $197,800.00
You will have the opportunity to establish manufacturing platforms and guide product development through all stages of development to ensure project advancement. This role is based in Florham Park, NJ In this role a typical day may include: Independently design studies aimed at optimizing and improving expansion and manufacturability of candidate products based on the biology and the target.
Design and execute experiments using approaches such as DOE or QBD, maintain detailed records of results, and present results to multi-disciplinary teams and leadership. Apply DOE/DQB for process characterization, establish process parameters, and contribute to CMC sections of regulatory filings.
Develop cell isolation, enrichment, separation and formulation protocols and technologies/ platforms to support product development. Develop processes that integrate innovative approaches to increase the functional capability and yield of gd T cells.
Relying on an in-depth CAR-T background, perform statistical analyses using product attribute data to assist, guide, and execute comparability studies. Develop and oversee tech transfer of protocols to CDMO. Collaborate with SME(s) at CDMOs to deliver timely and accurate technical solutions to resolve investigations and improve manufacturing performance and reliability. Present experimental outcomes, process analytics, and data trends to
larger cross functional groups and leadership. T his role may be for you if you: Enjoy the challenge of developing and improving processes for CAR-T manufacture.
Desire an opportunity to make key and highly visible contributions. Have a sound understanding in various approaches for CAR-T manufacture. Enjoy working in a matrix environment and guiding collaborations. To be considered for this role, you must have a Ph. D. + 6 years in immunology or bioengineering discipline with relevant industry experience, including cell therapy process development. We need someone with extensive hands-on experience in cell culture (primary cells and cell lines), aseptic culture, as well as genetic modification of cells using transduction and/or transfection.
Experience with gamma delta and other T cell lineages is needed. Experience in establishing cell therapy manufacturing processes and improving scalable upstream processes in the PD setting is required. Experience using wave rocker systems, benchtop bioreactors, Sepax, LOVO, and closed harvest systems will be needed. Familiarity with flow cytometry assays and other cell-based characterization assays (i. e. cytokine release and cytolytic assays) is a plus. Proven experience in the transfer of technologies/processes.
Demonstrated capability to conduct/document complex manufacturing processes, familiarity with FDA guidance's, and an understanding of GMP GDP/quality is preferred. Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process.
Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U. S. If you are outside the U. S, please speak with your recruiter about salaries and benefits in your location. Salary Range (annually) $121,200.00 - $197,800.00
of T cell biology, with a main emphasis on harnessing immunoregulatory mechanisms for reestablishing immune and tissue homeostasis under inflammatory conditions. The candidate will be expected to work independently and collaboratively on pipeline projects and will be responsible for advancing exciting and novel research stage programs into early clinical development, providing both scientific and technical expertise and generating solid proof of concept data.
No prior industry experience is required, but an open and curious scientific mind is essential. Excellent communication skills, will facilitate fruitful and open collaborations with other labs in immunology, regenerative medicine,
human genetics, biomarker discovery and early clinical development. Time and space will be provided to drive both pipeline research and also explore new biologies and pathways for new target discovery.
Using state of the art techniques and technologies, the candidate will have the capacity to develop in vitro and in vivo skills to test the involvement of novel pathways and molecules in the pathogenesis of inflammatory diseases and to identify the mechanism of action (MOA) of new targets. Strong candidates for this position will meet most of the following requirements: Ph D degree and post-doctoral experience in immunology, molecular biology, biochemistry or related field. A strong background
in T cell immunology is desirable. Demonstrated record of professional achievement in the form of high-quality publications.
Extensive hands-on experience in cellular and molecular immunology techniques including primary cell isolation from tissues, in vitro immunological assays, multi-dimensional flow cytometry and in vivo animal models. Experience with state-of-the-art precision genome editing technologies and their application for cell engineering is of particular interest. Experience with analysis of data from genomic sequencing, sc RNA-seq, TCR-seq, CITE-seq or spatial transcriptomics is a plus. Independently designing, executing and interpreting experiments.
Have excellent communication skills and willing to work in a collaborative environment and core lab. Can present research at intra- and inter-departmental meetings. Relocation benefits are available for this job postingThe expected salary range for this position based on the primary location of California is $98,200 and $182,400 of hiring range. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits#LI-JD1#researcherjob Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, interactionual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
evaluating therapeutic candidates in these models. A strong emphasis on creativity and ingenuity to challenge existing dogmas and investigate unsolved problems in genetics medicines will be required. Your immunology expertise combined with Regeneron's technology platforms, including viral and non-viral gene therapy, CRISPR-mediated gene editing, Veloci Gene transgenic mouse models, and the extensive catalog of fully human therapeutic antibodies, will be used to make immediate contributions to the field of immunology of genetics medicines.
As a Sr. Scientist, a typical day may include the following: Design, perform, analyze, and troubleshoot in vitro and in vivo mouse experiments to investigate
and validate therapeutic targets Design, coordinate, analyze large animal model immunology-focused experiments with external vendors to inform clinical program development Design and run animal/human ELISpots, immunophenotyping, and other relevant T cell assays Collaborate with team members and provide immunological wisdom Provide occasional experimental support for existing late-stage preclinical assets in the pipeline Participate and present in departmental meetings and external conferences This role may be for you if: You enjoy working in an innovative and cross-functional team.
You have a passion for championing new immunomodulatory therapeutics. You have strong organizational, time-management,
and communication skills. You can effectively and rationally balance and prioritize multiple projects.
This role requires a Ph. D. in immunology or a related field or a B. S. /M. S. with 10 years in an immunology-focused role. A strong background in in vivo T cell biology with experience in both humans and mouse models. Experience in developing and running immune functional assays of primary human blood/tissue products is highly desired. Familiarity with the unique challenges of immune responses in gene therapies and gene editing are a plus. #LI-onsite#RGMDoes this sound like you? Apply now to take your first steps toward living the Regeneron Way!
We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels! Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U.
S. If you are outside the U. S, please speak with your recruiter about salaries and benefits in your location. Salary Range (annually) $103,600.00 - $169,000.00
The candidate will also provide molecular biology support for the group including cloning and generation of expression constructs. KEY RESPONSIBILITIES: Perform purification of recombinant proteins using chromatographic methods. QC protein reagents for different applications.
Characterize proteins via SDS-PAGE, western blot, and other biochemical and biophysical methods. Perform cloning, mutagenesis, and generate expression vectors. Ensure that experiments are planned and coordinated cross-functionally, as well as executed effectively. Handle or communicate issues in a timely manner. Provide scientific insight to overcome challenges (e. g. protein solubility, purity, heterogeneity, yield).
Continuously drive for improved process performance. Generate associated technical reports and documents. Able to work independently as well as within a team environment.
Be accountable for technical performance and help drive results of the team. QUALIFICATIONS: BS or MS in molecular biology, biochemistry, biotechnology, or other relevant biological sciences. BS with typically 3 - 7 years or MS with typically 0 - 5 years of experience. Proven experience in protein expression and purification. Familiarity with the AKTA purification system is preferred but not required. Prior experience in supporting protein structural biology and biophysical characterizations of proteins is beneficial.
Experience in cloning and related molecular biology methods.
Good problem-solving and communication skills. Good record keeping and able to efficiently manage several projects simultaneously in a dynamic environment. Position will be filled at level commensurate with extent of education, experience, and accomplishment. Abb Vie is committed to operating with integrity, driving innovation, transforming lives, serving our community, and embracing diversity and inclusion. It is Abb Vie's policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, interaction (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, interactionual orientation, marital status, status as a protected veteran, or any other legally protected group status.
of my knowledge. Job Description About the role: At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.
Join Takeda as a Biomarker Senior Scientist where you will work in the Gastroenterology Drug Discovery Unit (GI DDU) and lead efforts focused on the discovery and validation of novel biomarkers for certain drug targets in liver fibrosis and other chronic liver diseases. You will have a strong scientific background
in liver fibrosis and/or metabolic diseases with experience in biomarker identification and development. You will also be responsible for biomarker discovery and validation efforts for novel targets and drug candidates and independently design and implement extensive biomarker research strategies to support multiple projects in collaboration with internal research teams, external partners and/or CROs.
As part of the Liver Disease Research team, you will report to the Associate Scientific Director and work with the GI DDU. How you will contribute: Develop and implement new biomarker concepts for the treatment of liver fibrosis and other chronic liver diseases. This includes biomarker identification,
development and validation etc. Develop and oversee novel scientific biomarker projects in collaboration with internal and external partners.
Establishes project direction integrating science, key technical knowledge, and program objectives. Manages relevant biomarker strategy for target and drug candidate discovery, validation and mechanism of action studies using contemporary in vitro/ in vivo methods and tools. Participate on cross-functional teams and provide technical leadership in area of expertise. Proactively identify complex obstacles to progress in specific areas; recommend and implement solutions using a diverse set of resources; regularly add value to research projects through creative ideas.
Prepare technical reports, summaries and quantitative analyses in written and/or oral form. Communicate with colleagues effectively. Present data to other scientific staff or cross-functional project team; may present data/posters to external research or scientific community and publish research results as appropriate. Act as a biomarker lead to be involved in different stages of portfolio projects to provide input and contribute to Go or No Go decisions for various milestones. Performs as a role model supporting Takeda culture and follow policies.
Minimum Requirements/Qualifications: Ph. D. degree in biology, cardio/metabolic diseases, or immunology or molecular pharmacology with 3+ years relevant post-doc experience or equivalent drug discovery experience in a biotech or medical industry research setting with an additional 2+ years of experience, or MS with 9+ years of experience, or BS with 11+ years' experience. Previous experience in relevant protein and RNA-based assays as well as use of multiomic approaches for biomarker discovery, validation or development is required. Previous experience in NASH/chronic liver disease or fibrotic diseases or understanding of liver disease pathogenesis and pre-clinical therapeutic mechanisms of action research.
Demonstrated ability to independently design and solve scientific problems using multiple, state-of-the-art technologies, experimental methods, and approaches is required. Demonstrated ability to generate and implement a biomarker discovery strategy for a program in an industry setting is required. Previous experience and lab skills to address various types of biomarkers, modalities, and matrices, across animal models and human samples is preferred. Previous experience with translational biomarker research and working experience with clinical samples is preferred.
Previous experience of using Omics platforms and collaboration with computational biologists. Good understanding of current liver fibrosis biomarkers is a plus. Good project management skills with a good understanding in various scientific disciplines in drug discovery (Pharmacology, Toxicology, DMPK, etc. ) is a plus. Demonstrated track record by publications in scientific journals. Good communication skills (oral, written, and presentation) and a good team player. What Takeda can offer you: Comprehensive Healthcare: Medical, Dental, and Vision Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan Health & Wellness programs including onsite flu shots and health screenings Generous time off for vacation and the option to purchase additional vacation days Community Outreach Programs and company match of charitable contributions Family Planning Support Flexible Ways of Working Tuition reimbursement More about us: At Takeda, we are transforming patient care through the development of novel specialty medicals and best in class patient support programs.
Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work. Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Base Salary Range: $130,200.00 to $186,000.00, based on candidate professional experience level. Employees may also be eligible for Short-term and Long-Term Incentive benefits as well.
Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off. The final salary offered for this position may take into account a number of factors including, but not limited to, location, skills, education, and experience. In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply. #LI-SB1#LI-Onsite EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
Locations San Diego, CA Worker Type Employee Worker Sub-Type Regular Time Type Full time
digital pathology research for programs in clinical development. For this position, we are seeking a demonstrated scientific leader with a consistent and outstanding record of creativity and performance in digital pathology or spatial 'omics for cancer biology R&D, evidenced by peer reviewed publications in top tier journals, patent applications, and/or publicly available code repository.
As a Senior Principal Scientist, you are expected to: • Lead the application and development of digital pathology methods to extract disease biology insights and support innovative clinical development programs. • Actively and collaboratively promote scientific and technical innovation with other members
of the department, including subject matter experts in disease biology, companion diagnostics, and data science. • Direct and support publications in high quality scientific, technical, or medical journals.
• Represent the department and translational teams externally through interactions with computational collaborators. • Interact with key partners and investigators and effectively manage internal and external scientific collaborations. • Participate and thrive in an interactive, collaborative, and team-oriented culture. Who You Are: • Ph D degree in a relevant field (e. puter science, computational biology, bioinformatics, molecular biology, cancer biology). • Minimum of 7 years post-Ph
D experience, with demonstrated scientific leadership in digital pathology for oncology in academia and/or industry.
• Fluency with Python and data analysis using modern frameworks (e. g. R, Num Py). • Experience with image analysis, machine learning, and deep learning frameworks (e. g. Pytorch, Tensor Flow-Keras). • Enthusiasm for understanding and discerning the biological context of disease. • Excellent communication and collaboration skills. The expected salary range for this position based on the primary location of South San Francisco, CA is $169,800-315,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.
A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits#g CSGenentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, interactionual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
oncology digital pathology research for programs in clinical development. For this position, we are seeking a demonstrated scientific leader with a consistent and outstanding record of creativity and performance in digital pathology or spatial 'omics for cancer biology R&D, evidenced by peer reviewed publications in top tier journals, patent applications, and/or publicly available code repository.
As a Senior Principal Scientist, you are expected to: • Lead the application and development of digital pathology methods to extract disease biology insights and support innovative clinical development programs. • Actively and collaboratively promote scientific and technical innovation with
other members of the department, including subject matter experts in disease biology, companion diagnostics, and data science. • Direct and support publications in high quality scientific, technical, or medical journals.
• Represent the department and translational teams externally through interactions with computational collaborators. • Interact with key partners and investigators and effectively manage internal and external scientific collaborations. • Participate and thrive in an interactive, collaborative, and team-oriented culture. Who You Are: • Ph D degree in a relevant field (e. puter science, computational biology, bioinformatics, molecular biology, cancer biology). • Minimum
of 7 years post-Ph D experience, with demonstrated scientific leadership in digital pathology for oncology in academia and/or industry.
• Fluency with Python and data analysis using modern frameworks (e. g. R, Num Py). • Experience with image analysis, machine learning, and deep learning frameworks (e. g. Pytorch, Tensor Flow-Keras). • Enthusiasm for understanding and discerning the biological context of disease. • Excellent communication and collaboration skills. The expected salary range for this position based on the primary location of South San Francisco, CA is $169,800-315,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.
A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits#g CS Who we are A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.
Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We're focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.
Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, interactionual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. For more information about equal employment opportunity, visit our Genentech Careers Homepage. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
in cutting edge immunological research as part of our discovery efforts and to contribute to human health at every stage of drug discovery and development. You will have the opportunity to support a broad pipeline in autoimmune and inflammatory diseases by executing in vivo experiments as well as in vitro assays.
As a scientist, your typical day might include: Designing, planning, and/or performing in vivo studies using mouse models of autoimmunity and other inflammatory diseases including tumor models. Processing of organs for immune cell isolation and analysis. Maintaining, expanding, and/or modulating cells and evaluating using in vitro assays. Analysis of data using biological and
statistical software such as flowjo, excel, prism. Close collaborative interactions with teams across the organization. Documentation of experimental procedures and results.
This role may be for you if you: Prefer working in an innovative and team-driven environment. Possess excellent organizational skills. Communicate openly and frequently with manager and team members. Exhibit strong communication and critical thinking skills. Enjoy creativity, independent thinking, and finding solutions to seemingly " impossible" problems. Seek an opportunity to constantly grow and learn about new areas through collaborative projects across multiple teams. To be considered for this role,
you must have a Ph D with 5 years of relevant experience. Training in the proper handling and care of mice and the collection and processing of blood and tissue samples is strongly preferred.
Experience in techniques including tissue culture (maintenance of transformed and primary cells), cell-based assays, and flow cytometry is highly desirable. You will have the opportunity to engage with multiple projects beyond autoimmunity in a fast-paced and data-driven environment with both basic research and pipeline implications. #LI-onsite Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U. S. If you are outside the U.
S, please speak with your recruiter about salaries and benefits in your location. Salary Range (annually) $103,600.00 - $169,000.00
therapeutic strategies and approaches. The qualified candidate will also be responsible for recommending, adapting and developing analytical methods for protein characterization. You must have in-depth knowledge of macromolecular physical chemistry especially solution interactions and hands-on experience in protein characterization using a variety of analytical tools.
The candidate is encouraged to be proficient with experimental design and an effective communicator of ideas, project goals and results to team members within the group and with colleagues in collaborating departments. You will proactively identify issues and develop solutions in a collaborative multidisciplinary environment
is crucial. The successful candidate is expected to also lead and build an effective team of scientists and be responsible their career development. A day as a Sr.
Principal Scientist looks like: Participates in and leads all aspects of protein or new modality characterization to provide molecular profiles and developability backssments of therapeutic assets, that support the pipeline, in a timely manner and aligned with partner functions. Reviews the literature and, drawing on in-depth knowledge and experience, designs experiments that solve biophysical problems for key collaborators. Has fundamental knowledge of assay qualification and statistical experimental design and decision making.
Supervises and supports junior scientists with critical data review as well as career development.
Builds an effective molecular characterization team. Ability and enthusiasm for independently learning new methods and softwares. Is a go-to resource for explaining and solving biophysical problems. Provides biophysical support and analytical development for both upstream and downstream functional groups; helps solve problems in real-time. Practical knowledge of downstream purification and formulation development of biologics and drug product profiles aligned with therapeutic strategies. Has generally good technical writing skills. Documents experiments, results and findings in electronic laboratory notebook; presents work at group and department meetings; contributes to drafting of analytical characterization reports, regulatory submission sections, and peer-reviewed articles for publication.
May serve as a team representative in drug candidate-specific development team meetings, and share knowledge and expertise of biophysical chemistry at cross-function team meetings. -Understands how to strategically position internal characterization efforts and collaborations within Protein Biochemistry and with Regeneron partner groups for optimum visibility.
This role may be for you if you have: Have excellent written and verbal communication skills. The successful candidate must be able to prepare slides, author reports and manuscripts for internal and external presentations, and peer-reviewed publications. The desire and ability to work in a team environment. A passion for science and innovation with a strong commitment to continual improvement and making significant contributions. Experience demonstrating broad, in-depth knowledge of macromolecular solution chemistry and biophysics and how this applies to proteins, polymers, viruses, particles and nucleic acids.
Experience designing and solve analytical methods and demonstrate the ability to plan, design, implement laboratory experimentation to advance projects. Experience with statistical and experimental design, molecular modeling, graphing and mathematical analysis softwares is a plus. In order to be considered qualified for this role, you must have a Ph D in medical sciences, biophysics, biochemistry, chemical engineering or equivalent with at least 5 years post-doctoral training combined with industry experience in characterization of therapeutic protein candidates (and/or AAVs, oligonuceleotides).
Knowledge of and demonstrated expertise operating light scattering, liquid chromatography, and capillary electrophoresis instrumentation is essential. Experience in spectroscopic (e. g. CD, fluorescence, and/or FTIR) principles and applications for analysis of proteins, size-based (AUC, LC, MALS) and charge-based (e. g. ic IEF, IEX) separation techniques is important. In-silico modeling skills are a bonus. Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U. S. If you are outside the U. S, please speak with your recruiter about salaries and benefits in your location.
Salary Range (annually) $141,800.00 - $231,400.00
