Lewy Body, Alzheimer's, Fronto-Temporal Dementia, Motor Neuron Disorders, Autism Spectrum Disorder, Schizophrenia, Depression, and Pain. In this role, you will support target research and validation, development of new technologies, creation of disease models and preclinical development of novel therapeutics to treat Parkinson's disease and other neurodegenerative diseases.
As an Associate Scientist, a typical day might include: Conducting experiments to study and target the pathophysiological mechanisms of Parkinson's disease and other neurodegenerative disorders. Testing novel therapeutic strategies in animal models. Planning, initiating, and completing in vivo experiments: Mouse handling
and monitoring, behavioral assays, anesthesia, dosing (IV, IP, SQ, RO), surgeries (including stereotaxic surgeries), dissections and sample collections (brain, peripheral tissues and biofluids).
Evaluating misfolded protein uptake, aggregation and spread using molecular biology techniques, biochemistry and immunohistochemistry Surveying literature to expand knowledge, optimize and develop new assays and bring new ideas to the table. Performing sophisticated data analysis as well as troubleshooting with minimal direction. Becoming an active participant of teamwork within the neuroscience department and collaborations with cross-functional groups. Keeping well-organized records of experiments.
Communicating and reporting findings at group meetings.
This role may be for you if you: Enjoy working in a highly collaborative and fast-paced environment. Possess strong organizational and time management skills to advance projects in parallel optimally. Exhibit excellent communication and presentation skills. Demonstrate scientific rigor and pay attention to details. To be considered for this role, you must have at minimum of Bachelor of Science + 2 years (minimum) experience or a Master of Science with experience in Neuroscience, Biology, or a related field. You should also have hands-on experience in a laboratory research setting; Industry or academic experience with in vivo models of neurodegenerative diseases is highly desirable, experience with animal handling is required; Experience with molecular, cellular, biochemical, behavioral methods for the study of the nervous system is preferred ; Excellent verbal and communication skills; Ability to work both independently and in a team environment are required.
Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), interaction, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, interactionual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations.
We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need. The salary ranges provided are shown in accordance with U. S. law and apply to U. S. based positions, where the hired candidate will be located in the U. S. If you are outside the U. S, please speak with your recruiter about salaries and benefits in your location. Salary Range (annually) $66,400.00 - $103,800.00
and biological scientists to perform translational oncology research around multimodal translational data sets for programs in clinical development. For this position, we are seeking a demonstrated scientific leader with a consistent and outstanding record of creativity and performance in multimodal data integration and analysis for cancer biology R&D, evidenced by peer reviewed publications in top tier journals, patent applications, and/or publicly available code repository.
As a Principal AI Scientist, you are expected to: Lead advanced machine learning and analytical method application to extract disease biology insights and support innovative clinical development programs and publications
on multimodal translational data sets that include single cell and spatial 'omics, RNAseq, ct DNA, digital pathology, and clinical data. Actively and collaboratively promote scientific and technical innovation with other members of the Department.
Direct and support publications in high quality scientific, technical or medical journals. Represent the department and translational teams externally through interactions with our key computational collaborators. Interact with key partners and investigators and effectively manage internal and external scientific collaborations. Participate and thrive in an interactive, collaborative, and team-oriented culture. Who You Are Ph D degree in a relevant
field (e. puter science, computational biology, bioinformatics, molecular biology, cancer biology, genomics).
Minimum of 3 years post-Ph D experience, with demonstrated scientific leadership in integrating, analyzing, and interpreting multimodal biological data in an academic and/or industry setting. Fluency with Python and data analysis using modern frameworks for deep learning (e. g. Pytorch, Tensor Flow-Keras). Experience with RNAseq data, systems biology tools, and pathway analysis. Excellent communication and collaboration skills. Experience with image analysis methods, particularly around spatial biology, is desirable. The expected salary range for this position based on the primary location of South San Francisco, CA is $165,600- $307,500.
Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits#g CS Who we are A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases.
Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work. Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve.
We're focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work. Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, interactionual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
For more information about equal employment opportunity, visit our Genentech Careers Homepage. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers. /working-with-us. The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at
the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies and transforming response and durability rates for cancer patients.
Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies. We are seeking a highly motivated and experienced individual with deep translational expertise to join the Translational Development team within the Tumor Microenvironment Thematic Research Center (TME TRC) at Bristol Myers Squibb in Redwood City, CA. Position
Responsibilities: In this role as Senior Principal Scientist, Translational Biomarker Lead, within the TME TRC Translational Development team, the ideal candidate: Designs, develops, establishes, and executes well-crafted asset-level oncology translational plans and biomarker strategies for First In Human through Proof of Concept studies within the TME TRC, focused on mechanism of action, target engagement and pharmacodynamic biomarker assays and potential clinical trial patient stratification and selection assays.
Accountable for creation and analysis of the assay development and clinical sample analysis plans, budgets, and data, such as generating qualification/validation plans and study reports, developing SOPs, reviewing qualification/validation reports, and contributing to, and reviewing all, pertinent documentation for assigned programs in collaboration with relevant internal subject matter experts Effectively partners within a highly matrixed organization within the Translational Development group, within the TME TRC, with oncology program colleagues & with external partners to deliver high-quality biomarker data and drive the advancement of therapeutic candidates.
Integrates discovery, translational research and other relevant assay information and data, along with logistics and quality considerations, to inform highly complex ideas, activities, and projects.
Accountable for providing scientific input and biomarker expertise across all aspects of early development plans and collaborations (such clinical protocols, sample collection tables, sample collection instructions and logistics, scopes of work, data transfer agreements, validation reports, study reports, central lab logistics, posters, publications, investigator brochures, INDs, regulatory documents, etc. ) Progresses translational plans into implementation and execution via leading Translational Subteams, monitoring and tracking assay and analysis status and deliverables, via collaboration with internal technical assay execution and/or execution with external contract research organizations (CROs) and/or specialty testing laboratories Supports due diligence, collaboration and asset integration activities as needed Proactively provides insight into novel ways to incorporate biomarkers into clinical designs to enable early understanding of emerging drug profiles, as well as input around tumor types and potential impact of biomarkers on internal decision making.
Provides oversight to progress validated biomarkers into development of diagnostic assays, as needed Participates in strategic review and input to presentations, publications and internal/ external communications along with accountable program leadership and in governance forums Develops solutions and courses of action for senior staff, including identification of risks and risk mitigations Shares expertise, experience, lessons learned and knowledge with translational and other relevant scientific experts and colleagues across the organization Experience = Basic Qualifications: Bachelor's Degree 10+ years of academic and / or industry experience Or Master's Degree 8+ years of academic and / or industry experience Or Ph.
D. or equivalent advanced degree in the Life Sciences 6+ years of academic and / or industry experience 2+ years of leadership experience Preferred Qualifications: Ph D or MD/Ph D with 7+ years of relevant industry experience in the drug development process, preferred within oncology translational biomarker roles and with solid tumor and immune oncology experience Experience from FIH through at least phase 2 trials, including directly contributing to clinical translational and biomarker components of study protocols, laboratory manuals, investigator brochures, regulatory documents, and INDs Experience interfacing with clinical teams and presenting at strategic meetings, and demonstrated ability to lead and influence others in a highly matrixed work environment Working knowledge of all functional areas of drug development, including, biology, toxicology, clinical development, diagnostic development, etc Demonstrated scientific acumen and mechanistic understanding of disease biology and experience in oncology and immuno-oncology drug development (small molecule and biologics) Excellent communication skills and comfortable working in a fast-paced environment where speed is paramount Experience in the design, execution and generation of clinical trial translational biomarker assays and data in oncology across multiple technologies and sample types (e.
g. genomics, immunohistochemistry, flow cytometry, immunoassay and other technologies) in various stages of clinical development Ability to effectively collaborate with internal and external partners (e. g. CROs, specialty labs, etc. ) Comfortable working in a fast-paced environment The starting compensation for this job is a range from $159,000.00 - $185,000.00, plus incentive cash and stock opportunities (based on eligibility).
The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience. Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site. Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, shop, dental and vision care.
Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility.
Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program. BMSONCRDBMSDDTMRCA#LI-Hybrid If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as " Transforming patients' lives through science™ " every BMS employee plays an integral role in work that goes far beyond ordinary.
Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues. On-site Protocol Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to xyz X@.
Visit careers. /eeo-accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
