Job Opportunities in Massachusetts

of my knowledge. Job Description About the role: At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

The vision of Takeda is to build a world-class Cell Therapy team and deliver allogeneic innate cell therapy product to bring hope to both hematological and solid tumor patients. Oncology Cell Therapy Innovation is missioned to develop innovate innate cell platform and novel engineering approaches to drive discovery

pipeline for Takeda Cell Therapy The Oncology Cell therapy Innovation team is seeking experienced molecular biologist who has a background in cancer immunology, genetic engineering especially non-viral mediated gene editing.

As a senior member of the team, you will play an important role in optimizing cell therapy platforms, e. g. CAR-NK, CAR-γδ T, to improve the biological function (potency and persistence) of cell therapy products, based on solid understanding of innate cell biology, cancer/immune biology in tumor microenvironment and genetic engineering. You will lead discovery projects and collaborate with colleagues within department and cross-function teams to drive the development

of Cell Therapy discovery platforms. How you will contribute: Contribute to discovery projects by independently designing and developing well-defined mechanistic experiments and projects within oncology cell therapy research.

Lead from the lab to advance novel and differentiated cell therapy products toward clinical milestones, by working collaboratively with internal cross-functional teams and external partners. Design, execute, and interpret functional in vivo, in vitro, and ex vivo assays to understand the mechanism-of-action and play an active role in subsequent scientific discussions to drive decisions. Propose novel projects based on internal results, external partners, and published reports and demonstrate leadership through communication of study plans/value, and research results Skill and breadth of knowledge in a scientific field Stay current with scientific development (e.

petitive landscape, new technology, new research portfolio, and new partnership) Scientific leadership and establish rigorous standards for execution effectiveness Have managerial responsibility Independently control workload and demands Scientifically independent Scientific driver for research strategy that impacts group internally and outside area of function Initiate and lead external interactions and collaborations Frequent contact with internal and external personnel at multiple management levels Elect approaches for new tasks and provide strategic project recommendations Minimum Requirements/Qualifications: Ph.

D. in Immunology, Biology, Genetic Engineering, or related discipline. Minimum of 6+ years relevant medical industry/academic experience post-graduation Hands on experience with CRISPR-, transposon-mediated genome engineering in multiple cell types. Independently design sg RNAs, constructs for KO and KI through non-viral (plasmid, self-replicating vectors, EP, LNP) methods.

Profound skills in analytical methods such as flow cytometry, dd PCR, real-time PCR, off-targets evaluation, NGS etc. Previous experience with CAR-T, CAR-NK, CAR-γδ T, TCR-T cell immunotherapies, including cell culture, immune cell activation/expansion, viral transduction in vitro and in vivo immune cell characterization and function backssment, such as, multi-color flow immunophenotype, multiplex cytokine measurement, cytotoxicity assay is a plus Excellent written and verbal communication skills, detail-oriented organization skills, and team collaboration skills.

Track record of publications to demonstrate scientific establishment. What Takeda can offer you: Comprehensive Healthcare: Medical, Dental, and Vision Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan Health & Wellness programs including onsite flu shots and health screenings Generous time off for vacation and the option to purchase additional vacation days Community Outreach Programs and company match of charitable contributions Family Planning Support Flexible Ways of Working Tuition reimbursement More about us: At Takeda, we are transforming patient care through the development of novel specialty medicals and best in class patient support programs.

Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work. Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.

EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations Boston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time

of my knowledge. Job Description Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Senior Scientist / Principal Scientist, Oncology Cell Therapy Innovation in our Cambridge, MA office.

At Takeda, we are transforming the medical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united

by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. Here, you will be a vital contributor to our inspiring, bold mission.

The vision of Takeda is to build a world-class Cell Therapy team and deliver allogeneic innate cell therapy products to bring hope to both hematological and solid tumor patients. Oncology Cell Therapy Innovation is missioned to develop innovate innate cell platforms and novel engineering approaches to drive the discovery pipeline for Takeda Cell Therapy. ROLE OVERVIEW: This position is seeking an experienced and highly motivated immunologist, who has a solid background in immunology, especially immuno-oncology and

innate cell biology, to join the Cell Therapy Experimental Immunology team.

We are looking for someone who is highly dedicated and driven to advance new therapies to patients and who has a strong work ethic, drive and collaborative mindset. The candidate will lead efforts in identifying new ways to optimize CAR-NK and CAR-γδ T cell platforms byimproving our understanding of the basic biology of NK and γδ T cells. The focus will be in discovering new ways to improve potency, persistence and immune modulation through developing a solid understanding of activation, survival, costimulation, differentiation, and suppressive mechanisms affecting these cells. The principal scientist will lead discovery projects and collaborate with colleagues within and across departments.

How you will contribute: Contribute to pre-clinical/discovery work by designing, executing and leading experiments to further understand key pathways and mechanisms driving NK and γδ T cells biology Lead from the lab to advance novel and differentiated cell therapy products toward clinical milestones, by working collaboratively with internal cross-functional teams and external partners. Design, execute, and interpret functional in vivo, in vitro, and ex vivo assays to understand the mechanism-of-action and play an active role in subsequent scientific discussions to drive decisions.

Propose novel projects based on internal results, external partners, and published reports and demonstrate leadership through effective communication of study plans/value, and research results. Prepare and present comprehensive technical or project reports and formal presentations/posters to full range of internal/external audiences. Ability to work independently and prioritize work in a fast-paced environment. Maintain laboratory notebooks and follow laboratory practices in compliance. Contribute to IND report and documentation.

Collaborate with cross-function teams and contribute in matrix-based project groups Other job duties as assigned. Minimum Requirements/Qualifications: Ph D degree in a scientific discipline with 6+ years experience, or MS with 12+ years experience, or BS with 14+ years experience Minimum of 8+ years relevant medical industry/academic experience post-graduation Hands-on experience with CAR-T, CAR-NK, CAR-γδ T, or TCR-T cell therapies/immunotherapies is required, including cell culture, immune cell activation/expansion, cytotoxicity assays, sc RNAseq and high-throughput screening.

Profound skills in in vitro and in vivo immune cell characterization and functional backssment, such as, multi-color flow immunophenotyping, multiplex cytokine measurements, cytotoxicity assays, and other molecular based assays. Experience with lentiviral transduction/CRISPR mediated KO/KI. Excellent written and verbal communication skills, detail-oriented organization skills, and team collaboration skills. Track record of publications to demonstrate scientific establishment. What Takeda can offer you: Comprehensive Healthcare: Medical, Dental, and Vision Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan Health & Wellness programs including onsite flu shots and health screenings Generous time off for vacation and the option to purchase additional vacation days Community Outreach Programs and company match of charitable contributions Family Planning Support Flexible Ways of Working Tuition reimbursement More about us: At Takeda, we are transforming patient care through the development of novel specialty medicals and best in class patient support programs.

Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world. In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply. #LI-AA1 EEO Statement Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

Locations Boston, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time

areas where we believe we can really change the course of medicine and bring big new ideas to life. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person. Astra Zeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death.

A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and haematological cancers. This Opportunity We are seeking a highly motivated and independent Scientist in cancer pharmacology

with a track record of scientific excellence in the area of in vivo cancer modeling, to join our In Vivo Pharmacology Team in Waltham, MA USA. As a Scientist you will be a key member of a team focused on delivering all aspects of in vivo pharmacology support.

You will bring your theoretical and practical expertise to establish assay systems and deliver datasets that will have direct impact on the drug discovery process and pipeline. Key Duties and Responsibilities Working in this laboratory-based position within Oncology Research you will develop, design, conduct and analyze in vivo experiments to backss the function of our candidate oncology drugs and dissect the mechanism of action

of novel cancer therapeutics. You will be expected to support cross-functional teams and work collaboratively with project leaders to ensure the timely generation and dissemination of critical program data, and contribute to scientific publication goals.

As a highly organized, self-motivated individual with a strong background in laboratory science you will stay up to date with relevant technical and intellectual scientific expertise in tumor biology, pharmacology and cancer modeling and have a genuine passion for this field of research. Essential Requirements B. S, in Biology, Pharmacology or other related scientific discipline with 3-6 yrs. relevant scientific experience; M.

S. - 2-5 yrs. MS desired but not required. Experience developing and working with complex in vivo models of cancer, such as cell line derived xenograft (solid and hematological tumors) patient derived xenograft (PDX), syngeneic and autochthonous mouse models. Experience delivering in vivo pharmacology studies in mouse tumor models, including dose-finding tolerability studies, PK/PD and efficacy studies. Experience with a range of in vitro skills, e. g. cell culture, molecular biology, immunoblotting, flow cytometry and ELISA. Works independently, backsses and reports data in a clear and concise manner, with a clear understanding of its implications within the overall context of drug discovery.

Maintains a well-developed understanding of approaches to drug discovery and applies a broader functional knowledge of the procedures used by diverse project groups to support the department where needed. Strong interpersonal and collaboration skills together with evidence of delivery in a team-oriented, collaborative environment. Excellent communication and presentation skills Desirable Requirements Biotechnology or medical industry experience preferred but not essential.

Experience with orthotopic xenograft and humanized models of cancer. Experience using biologics including, peptides, antibodies, or antibody-drug conjugates. Knowledge of the medical industry drug discovery process. About the Waltham Site Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park Bio Hub, just west of the city center. Our Bio Hub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science.

We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world's most vibrant research centers. Our Waltham site offers a variety of amenities to help book productivity and help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center.

This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility.

Join us in our unique and ambitious world. So, what's next- Are you already envisioning yourself joining our team? Good! We can't wait to hear from you! If you're curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner. Closing Date: January 10, 2024 Competitive remuneration and benefits apply We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

Where can I find out more? Our Social Media, Follow Astra Zeneca on Linked In /company/1603/ Follow Astra Zeneca on Facebook /astrazenecacareers/ Follow Astra Zeneca on Instagram /astrazeneca_careers/? hl=en Astra Zeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.

We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Date Posted 13-Dec-2023 Closing Date 09-Jan-2024Astra Zeneca embraces diversity and equality of opportunity.

We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e. g. race, color, religion, interaction, interactionual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

Astra Zeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.