by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow n Research & Development, LLC is part of the Janssen medical Companies.
The Senior Scientist modeling approaches used may include physiologically based pharmacokinetic modeling, mechanistic PK/PD modeling, and/or systems pharmacology modeling to help (a) predict preclinical and clinical PK profiles (b) quantify exposure/ response relationships for target engagement biomarkers, efficacy, and potential adverse effects, and (c)
guide in vivo and in vitro experimental designs that will be most informative for modeling. Key Responsibilities: Apply Pharmacokinetic/Pharmacodynamic (PK/PD) modeling to drive project team decisions from early discovery through early clinical studies.
Contribute to guiding modeling and simulation strategies within the organization. Act as a key member of discovery project teams and interact closely with biology, chemistry, and other drug metabolism and pharmacokinetic (DMPK) project members to help craft the most appropriate preclinical and early clinical studies and the associated quantitative model-based analyses to advise candidate selection and dosing recommendations. Education:
Ph D in Pharmacology, Engineering, Mathematics, Physics, or related fields is required.
Outstanding candidates with a Master's degree and at least 8 years of relevant industry experience may also be considered. Experience and Skills: Familiarity with principles of pharmacokinetics and pharmacodynamics and experience performing PK and/or PK/PD modeling is preferred. Proven skills in mathematical modeling and simulation, supported by peer-reviewed publications is highly desired. Excellent interpersonal, organizational, oral/written communication and teamwork skills are required. Other: This position may require up 10% travel. The anticipated base pay range for this position is $111,000 to $192,050.
The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market. Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www. careers.
leaders in the field of immunology having developed the anti-TL1A monoclonal antibody MK-7240 (formerly PRA023) and continue to lead with new indications and modalities targeting the TL1A pathway. The department of Immunology Discovery and Translational Sciences (IDTS) leads and supports our company's pipeline programs encompassing early target discovery and validation, drug discovery, translational sciences, and precision medicine in collaboration with multi-disciplinary teams at our company, including bioinformatics, immunology discovery and chemical biology, antibody discovery, and clinical development.
IDTS is currently seeking a highly motivated, detail-oriented Sr. Scientist with
a passion for improving patient lives to support internal discovery efforts at our Research Division's San Diego. The Sr. Scientist will work in a matrixed environment with a focus on immune targets and leveraging genetics to stratify patients for drug treatment.
Main job duties include, but are not limited to: Working with team leaders to develop strategy and drive drug discovery, translational medicine, and precision medicine / diagnostics (Dx) discovery programs forward Representing IDTS in working groups and/or project teams Collaborating with bioinformatics team members to generate datasets supporting translational medicine and Dx discovery Developing and running cell-based assays
to characterize drug target pathway activity in primary cells derived from patient samples Using immunoassay-based methods to determine cytokine and target levels in biological samples Analyzing data and communicate findings to team members Education Minimum Requirements: Ph D in immunology, cell biology, or related biomedical science and zero (0+) relevant academia and/or industry experience MS in immunology, cell biology, or related biomedical science with five (5) years relevant academia and/or industry experience BS in immunology, cell biology, or related biomedical science with seven (7) years relevant academia and/or industry experience Required Experience and Skills: Understanding of immune diseases, including current research and drugs in development Strong cell culture skills including developing cell-based functional assays in primary cells (e.
g. PBMCs) Proficiency in data analysis using Excel and Prism (Graph Pad) Experience with immunoassay platforms (e. g. ELISA, multiplex of our company) Experience in multi-color flow cytometry Ability to follow procedures and document experiments Strong communication and interpersonal skills with an eagerness to work with and support colleagues across the organization in a matrixed environment Preferred Experience and Skills: Understanding of the drug discovery process with industry experience Experience in developing and running transcriptomics experiments (bulk and single cell RNAseq) Background in biomarker discovery and development Understanding of principles of bioinformatics Background in genetics of immune disease and molecular diagnostics #Eligiblefor ERP Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders).
Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated.
Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission. Current Employees apply HERE Current Contingent Workers apply HERE US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, interaction, interactionual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U. S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement Pay Transparency Nondiscrimination We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together.
The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts U. S. Hybrid Work Model Effective September 5, 2023, employees in office-based positions in the U. S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.
This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely.
Please note, this Hybrid work model guidance also does not apply to roles that have been designated as " remote"Under New York State, Colorado State, Washington State, and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate's relevant skills, experience, and education.
Expected salary range: $107,600.00 - $169,400.00Available benefits include bonus eligibility, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. For Washington State Jobs, a summary of benefits is listed here. Search Firm Representatives Please Read Carefully Merck & Co. Inc. Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.
No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. Employee Status: Regular Relocation: Domestic VISA Sponsorship: Yes Travel Requirements: 10% Flexible Work Arrangements: On-Site Shift: 1st - Day Valid Driving License: No Hazardous Material(s): N/A Requisition ID: R272504PDN-9ad9c9c2-1e14-4563-b378-4b53b92b13e0
healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. Johnson & Johnson Innovative Medicine discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases.
Please visit http: // for more information. We are Johnson & Johnson Innovative Medicine. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it. Thriving on a diverse company culture, celebrating the
uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer. Johnson & Johnson Innovative Medicine Immunology has a history of bringing life-changing therapies to patients with immune-mediated diseases.
Translational Science and Medicine (TSM) is an integrated group of scientists composed of a clinical Translational Medicine (TM) team which conducts early clinical development and experimental medicine studies, and a Translational Science (TS) team which uses human disease data to support the portfolio from early development to late stage clinical assets. Together, the TSM group provides the key learnings/insights on the next wave of novel therapies
for patients. Organizationally, TSM serves as a pivotal bridge between Discovery Research and the later phase Clinical Development group.
TSM provides the necessary scientific and clinical expertise to advance an industry-leading pipeline of novel mechanism small molecules and biologic agents to address unmet need in immune-mediated diseases. TS has a broad remit stretching from support of discovery with human data to support target selection, through development of novel decision- making biomarkers for early phase clinical trials, target-centric indication sequencing and prioritization, and biomarker support of regulatory filings. TS has expertise in biomarker development, disease biology research and in the application of immunology and data science technologies to support drug discovery and development.
This is a position within the Translational Immunomics group of TSM. The group is responsible for delivering analysis of 'omics datasets (e. g. genetics, gene expression, proteomics) to support portfolio projects within the Immunology Therapeutic Area. The successful candidate will contribute to the computational biology and genomics strategy for Immunology programs and will be effective in the use of relevant computational tools to deliver analysis and interpretation of high-dimensional biological data across all aspects of portfolio development.
The Scientist will serve as a computational biology analyst in the immuno-dermatology area and will be accountable for analytical and platform support for drug development programs as well as providing strategic input to TSM colleagues. The candidate will bring an enthusiastic, rigorous and enterprise thinking mindset to Translational Immunomics team. Responsibilities are as follows: Effectively use relevant computational tools to deliver analyses of high-dimensional biological ('omics) data to support all aspects of portfolio development in immuno-dermatology Design and execution of data analysis, interpretation of results, documentation and generation of analysis reports Ensure delivery of completed data and analyses in support of key program milestones and drive technical excellence in translational science and biomarker research Contribute to the strategies enabling molecular understanding of immune driven human diseases, patient stratification and generation of biomarker-based endpoint Lead projects with internal groups/external collaborator Communicate analysis results to key stakeholders • Ph D degree in Bioinformatics, Computational Biology, Immunology or related field, with 3 years relevant experience is required.
• Documented experience and proficiency in analysis of NGS transcriptomics (single cell and bulk RNAseq) and proteomics datasets is required. • Proficiency in programming with R, Python, or similar language for 'omics analysis is required • Expertise in multimodal data integration is preferred. • Industry and/or translational research experience is highly preferred. • Experience working within cross-function teams is preferred. • Outstanding communication and collaboration skills are required.
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability. IMPACTIMM
the burden, and disability caused by neuropsychiatric diseases. At Janssen, we never stop working toward a future where disease is a thing of the past. We're the medical Companies of Johnson & Johnson, and you can count on us to keep working tirelessly to make that future a reality for patients everywhere, by fighting sickness with science, improving access with ingenuity, and healing hopelessness with heart.
We focus on areas of medicine where we can make the biggest difference: Cardiovascular & Metabolism, Immunology, Infectious Diseases & Vaccines, Neuroscience, Oncology, and Pulmonary Arterial Hypertension. Visit us: We are looking for an experienced, motivated, highly collaborative
neuroscientist to lead drug discovery programs from the hit identification stage to transition to the clinic. As part of our team you will work in partnership with multidisciplinary experts to advance novel therapies and develop translational plans to enable precision medicine.
The candidate should have experience in working in a medical environment and a track record in progressing projects through the various stages gates. Key Responsibilities: Responsible for delivering new molecular candidates for disease modifying approaches in our neuropsychiatry portfolio. Act as a leading expert within biological research and collaborate with cross-department teams (medicinal chemistry, DMPK,
toxicology, developability, clinical and biomarkers) to craft and guide the execution of decisional experiments.
Provide updates, documentation, and communication of project results to leadership. Manage outsourced studies at CROs and academic collaborators. Support the evaluation of external licensing opportunities. Proactively build a purpose driven environment by aligning Johnson & Johnson's Credo and Leadership Imperatives with the strategies and goals of the team and enterprise. Actively engage with the internal and external scientific community through publications and presentations. Education: Doctorate (Ph D) or equivalent in Neuroscience, Biomedical Sciences, Pharmacology or related area and 8 years or Masters Degree with 12 years of drug discovery experience in medical industry is required Experience and Skills: Required: Experience in leading drug discovery projects in multidisciplinary teams is required Extensive knowledge in drug discovery, translational science and neuroscience as evidenced by publication record is required Excellent oral and written communication skills, including preparation of presentations and reports.
Ability to synthesize scientific concepts into simple communication points is required Proven track record of working collaboratively in a fast-paced team environment, quickly acquire new technical skills and knowledge, and solve sophisticated technical & scientific problems is required Use of electronic lab notebooks and knowledge of data capture required for intellectual property protection and regulatory purposes is required This position may require up to 10% travel domestic or international Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer.
All qualified applicants will receive consideration for employment without regard to race, color, religion, interaction, interactionual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www. careers.
